Objective  To explore the application value of probiotics combined with compound polyethylene glycol powder+lactulose in bowel preparation for colonoscopy in patients with chronic constipation(CC).

Methods  CC patients who were to undergo colonoscopy from June 2022 to December 2023 in the Department of Gastroenterology of Zhejiang Putuo Hospital were included. Using the randomized numerical table method, the patients were randomly divided into the probiotic group (probiotics combined with compound polyethylene glycol powder + lactulose) and the control group (compound polyethylene glycol powder + lactulose). Bowel cleanliness [Boston Bowel Preparedness Scale (BBPS) score and bowel cleanliness efficiency], intestinal bubble score, colonoscopy quality indicators (polyp detection rate, adenoma detection rate, colonoscopy operation time, and colonoscopy completion rate), tolerability (tolerance rate and re-examination acceptance rate), and the incidence of adverse reactions were assessed and compared between the probiotic group and the control group.

Results  A total of 120 CC patients, 60 in each group, were included in the study, and the colonoscopy completion rate was 100.00% in both the probiotic and control groups. The left hemicolon score, middle colon score, right hemicolon score, BBPS score, bowel cleansing effective rate, and bowel bubble score satisfaction were significantly higher in the probiotic group than those in the control group (P<0.05); the difference between the polyp detection rate and adenoma detection rate of the two groups was not statistically significant (P>0.05). Compared with the control group, the colonoscopy operation time in the probiotic group was short, the tolerance rate and re-examination rate were high, and the incidence of adverse reactions was low (P<0.05).

Conclusion  Probiotics can improve the efficacy and safety of compound polyethylene glycol dispersions + lactulose in bowel preparation for colonoscopy in CC patients.

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