Objective  To compare and analyze the effects of application of phloroglucinol (PG) and diazepam (DZP) during the latent phase of labor on the delivery outcome of primiparous women.

Methods  Clinical data of women who delivered in Hangzhou Obstetrics and Gynecology Hospital from January 2022 to December 2023 were retrospectively analyzed. According to the medication regimen in the latent stage of labor, they were divided into PG group (PG 80 mg, intravenous push) and DZP group (DZP 10 mg, intravenous push). Cervical ripeness, duration of labor, delivery (cervical dilatation, 24 h postpartum hemorrhage, mode of delivery, and time to full opening of the uterus), neonatal Apgar score, and pregnancy-related adverse outcomes were compared between the two groups.

Results  A total of 162 patients were included in the study, with 83 in the PG group and 79 in the DZP group. The total cervical ripening rate in the PG group was significantly higher than that in the DZP group (P<0.05); the time of the first, second, third, and total labor were all shorter than those in the DZP group (P<0.05).The cervical dilatation in the PG group was significantly greater than that in the DZP group (P<0.05), the amount of postpartum 24 h hemorrhage and time to full opening of the uterine were significantly less than those in the DZP group (P<0.05), and the rate of transvaginal delivery was higher than that of DZP group (P<0.05). The differences in neonatal Apgar scores at 1 min and 5 min, the incidence of adverse maternal outcomes and the incidence of adverse neonatal outcomes between the two groups were not statistically significant (P>0.05).

Conclusion  Compared with DZP, the application of PG during the latency period can improve cervical ripeness, accelerate the progress of labor, and increase the rate of transvaginal delivery.

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