Objective  To explore the clinical efficacy and safety of donepezil (DNPQ) combined with butylphthalide sequential therapy (BST) in the treatment of Parkinson's syndrome (PS).

Methods  In this study, 104 patients with Parkinson's disease (PD) who were diagnosed and treated in the Department of Neurology of The Fourth Hospital of Changsha from January 2020 to November 2023 were randomly divided into a control group (butylphthalide soft capsule combined with DNPQ) and an observation group (BST combined with DNPQ). The main observation indicators of this study were the clinical efficacy and drug-related adverse reactions after 3 months of treatment. The secondary observation indicators were the cognitive function [Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE)], overall condition [Unified Parkinson's Disease Rating Scale (UPDRS)], activity of daily living (ADL), and oxidative stress-related cytokines [recombinant human Parkinson's disease protein 7 (PARK7), neurotrophic factor 3 (NT3), and C-reactive protein (CRP)] improvement after treatment.

Results  There were 52 patients in the experimental group and 52 patients in the control group. The treatment efficacy rate in the experimental group was significantly higher than that in the control group (P<0.05), while the incidence of adverse reactions was significantly lower than that in the control group (P<0.05). Before treatment, there were no significant differences in MoCA scores, MMSE scores, UPDRS scores, ADL scores, serum NT3, CRP, and PARK7 levels between the two groups (P>0.05). After treatment, the MoCA score, MMSE score, and ADL score in the experimental group were higher than those in the control group (P<0.05), while the UPDRS score was lower than that in the control group (P<0.05). After treatment, the serum NT3 level in the experimental group was higher than that in the control group (P<0.05), while the serum CRP and PARK7 levels were lower than those in the control group (P<0.05).

Conclusion  The combination of DNPQ and BST has better clinical efficacy and safety, which can improve cognitive function, ADL and oxidative stress -related cytokine content in patients with PS.

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