The chemical constituents of Justicia procumbens are mainly lignans, flavonoids, alkaloids, etc. It is commonly used in clinical practice as an adjunctive treatment for malaria, fevers, coughs of pulmonary fever, poisonous snake bites and other diseases. Modern pharmacological studies have shown that Justicia procumbens has anti-platelet aggregation, analgesic, anti-tumor and anti-inflammatory effects. In this review, the herbal evidence of Justicia procumbens was summarised in more detail, and the chemical composition, the pharmacological effects and clinical applications of Justicia procumbens were summarised in combination with domestic and international studies, and the quality marker (Q-Marker) of Justicia procumbens was predicted and analyzed on the basis of the Five Principles, network pharmacology, and traditional medicinal properties. The preliminary predictions of 6'-hydroxy justicidin A, 6'-hydroxy justicidin B, 6'-hydroxy justicidin C, justicidin B, Chinensinaphthol methyl ether, and kaempferol were used as the Q-Markers of Justicia procumbens with a view to provide a reference for the better development and utilisation of Justicia resources.

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