Atractylodis rhizoma is a perennial herb of the Asteraceae family, which mainly divided into A. chinensis (DC) Koidz and Atractyiodes lancea (Thunb) DC, with the effects of strengthening the spleen, drying dampness, brightening the eyes, etc. Atractylodis rhizoma is mainly used in the clinical treatment of spleen deficiency and dampness, night blindness, eye fatigue and other symptoms. According to the clinical effect, and modern pharmacological researches have confirmed, the Chinese herbal medicine Atractylodis rhizoma contains a variety of active ingredients, such as volatile oils, alkynes, glycosides, etc. In recent years, pharmacological studies on Atractylodis rhizoma have found that atractylodin in polyalkynes has good activity in anti-inflammation, treatment of bacterial resistance, and inhibition of cholangiocarcinoma cell migration, and its high biological activity may be related to the conjugated enyne structure. Therefore, this article summarizes the studies on chemical components and pharmacological effects of polyalkynes in Atractylodis rhizoma that have been published in recent years, and comprehensively expounds the research progress of polyalkynes in Atractylodis rhizoma, so as to provide reference for scientific researchers and promote the in- depth development and utilization of the medicinal value of Atractylodis rhizoma.

1.清·孙星衍, 孙冯翼, 辑. 神农本草经[M]. 北京: 人民卫生出版社, 1982: 21.

2.刘思佳, 姚杰, 宋雪, 等. 苍术属药用植物的化学成分、药理作用、临床应用概况[J]. 中华中医药学刊, 2023, 41(1): 151-154. [Liu SJ, Yao J, Song X, et al. Chemical composition, pharmacological effects and clinical application of Atractylodes atractylodes medicinal plants[J]. Chinese Archives of Traditional Chinese Medicine, 2023, 41(1): 151-154.] DOI: 10.13193/j.issn.1673-7717. 2023.01.034.

3.殷伟峰, 刘越, 王亚顺, 等. 基于天人相应思想探讨《神农本草经》中药物功效[J]. 江西中医药大学学报, 2018, 30(4): 7-9. [Yin WF, Liu Y, Wang YS, et al. An exploration of drugs efficacy in Shennong Bencao Jing Based on the thought of correspondence between man and universe[J]. Journal of Jiangxi University of Traditional Chinese Medicine, 2018, 30(4): 7-9.] DOI: CNKI:SUN:XYXB.0.2018-04-004.

4.梁·陶弘景, 编著. 本草经集注[M]. 北京: 人民卫生出版社, 1994: 197.

5.明·陈嘉谟, 编著. 本草蒙筌[M]. 北京: 中医古籍出版社, 2009: 33-34.

6.郑丽. 苍术属系统发育及药用植物白术的群体遗传和栽培起源研究[D]. 杭州: 浙江大学, 2013. https://cdmd.cnki.com.cn/Article/CDMD-10335-1014377861.htm.

7.庄丹, 秦靖, 王慧阳, 等. 苍术的药效成分研究进展[J]. 生物加工过程, 2021, 19(3): 306-313. [Zhuang D, Qin  J, Wang HY, et al. Medicinal compositions of Atractylodis rhizoma: a review[J]. Chinese Journal of Bioprocess Engineering, 2021, 19(3): 306-313.] DOI: 10.3969/j.issn. 1672-3678.2021.03.012.

8.李涵, 金香环, 赵百慧, 等. 北苍术的化学成分及药理活性的研究进展[J]. 吉林农业, 2019, (3): 72-73. DOI: 10.14025/j.cnki.jlny.2019.03.032.

9.姜宇珺. 四种苍术和白术差异性研究[D]. 沈阳: 辽宁中医药大学, 2020. DOI: 10.27213/d.cnki.glnzc.2020. 000386.

10.绪扩, 姜建双, 冯子明, 等. 茅苍术根茎中的2个新的多烯炔苷类化合物[J]. 中草药, 2020, 51(20): 5105-5113. [Xu K, Jiang JS, Feng  ZM, et al. Two new polyenylosides in the rhizome of Atractylodes atractylodes[J]. Chinese Traditional and Herbal Drugs, 2020, 51(20): 5105-5113.] DOI: 10.7501/j.issn.0253-2670.2020.20.001.

11.Xu K, Feng ZM, Yang YN, et al. Four new C10-polyacetylene glycosides from the rhizomes of Atractylodes lancea[J]. J Asian Nat Prod Res, 2017, 19(2): 121-127. DOI: 10.1080/10286020.2016.1247811.

12.Xu K, Jiang JS, Feng ZM, et al. Bioactive sesquiterpenoid and polyacetylene glycosides from Atractylodes lancea[J]. J Nat Prod, 2016, 79(6): 1567-1575. DOI: 10.1021/acs.jnatprod.6b00066.

13.绪扩, 冯子明, 杨桠楠, 等. 茅苍术根茎中的两个新化合物[J]. 有机化学, 2017, 37(11): 3019-3023. [Xu K, Feng ZM, Yang HN, et al. Two new compounds from rhizomes of atractylodes lancea[J]. Chinese Journal of Organic Chemistry, 2017, 37(11): 3019-3023.] DOI: 10.6023/cjoc201706031.

14.Ying J, Xu F, Chao C, et al. A new polyacetylene glycoside from the rhizomes of Atractylodes lancea[J]. Chinese Chem Lett, 2010, 21(7): 850-852. DOI: 10.1016/j.cclet.2010.03.026.

15.赵晋, 邓金宝, 黎雄, 等. 苍术聚炔类化学成分研究[J]. 中药新药与临床药理, 2015, 26(4): 525-528. [Zhao J, Deng JB, Li X, et al. Analysis of polyacetylenes from Rhizoma atractylodis[J]. Traditional Chinese Drug Research and Clinical Pharmacology, 2015, 26(4): 525-528.] DOI: 10.3969/j.issn.1003-9783.2015.04.023.

16.Resch M, Heilmann J, Steigel A, et al. Further phenols and polyacetylenes from the rhizomes of Atractylodes lancea and their anti-inflammatory activity[J]. Planta Med, 2001, 67(5): 437-442. DOI: 10.1055/s-2001-15817.

17.Kano Y, Komatsu K, Saito K, et al. A new polyacetylene compound from Atractylodes rhizome[J]. Chem Pharm Bull (Tokyo), 1989, 37(1): 193-194. DOI: 10.1248/CPB.37.193.

18.Lehner MS, Steigel A, Bauer R. Diacetoxy-subslituted polyacetylcnes from Atractylodes lancea[J]. Phytochemistry, 1997, 46(6): 1023-1028. DOI: info:doi/10.1016/S0031-9422(97)00342-7.

19.Jiao P, Tseng-Crank J, Corneliusen B, et al. Lipase inhibition and antiobesity effect of Atractylodes lancea[J]. Planta Med, 2014, 80(7): 577-582. DOI: 10.1055/s-0034-1368354.

20.Zhang Y, Peng X, Sun Z, et al. Diverse polyacetylenes from Atractylodes chinensis and their anti-osteoclastogenesis activity[J]. Fitoterapia, 2022, 161: 105233. DOI: 10.1016/j.fitote.2022.105233.

21.Sun ZJ, Zhang YT, Peng X, et al. Diverse sesquiterpenoids and polyacetylenes from Atractylodes lancea and their anti-osteoclastogenesis activity[J]. J Nat Prod, 2022, 85(4): 866-877. DOI: 10.1021/acs.jnatprod.1c00997.

22.蒋锡兰, 魏伟, 孙家英, 等. 内蒙苍术脂溶性部位化学成分研究[J]. 四川文理学院学报, 2020, 30(2): 30-36. [Jiang XL, Wei W, Sun JY, et al. Study on fat-soluble components from Inner Mongolia Atractylodis chinensis (DC) Koidz[J]. Sichuan University of Arts and Science Journal, 2020, 30(2): 30-36.] DOI: CNKI:SUN:DXSZ. 0.2020-02-006.

23.周媛媛, 高蕙蕊, 张然然, 等. 关苍术化学成分的研究[J]. 中成药, 2020, 42(10): 2640-2643. [Zhou  YY, Gao HR, Zhang RR, et al. Chemical constituents from Atractylodes japonica[J]. Chinese Traditional Patent Medicine, 2020, 42(10): 2640-2643.] DOI: 10.3969/j.issn. 1001-1528.2020.10.019.

24.Nakai Y, Sakakibara I, Hirakura K, et al. A new acetylenic compound from the rhizomes of Atractylodes chinensis and its absolute configuration[J]. Chem Pharm Bul (Tokyo), 2005, 53(12): 1580-1581. DOI: 10.1248/cpb.53.1580.

25.Pachaly P, Lansing A, Neugebauer M, et al. Acetylenes from Atractylis koreana[J]. Planta Medica, 1990, 56(5): 469-471. DOI: 10.1055/s-2006-961013.

26.Meng H, Li GY, Dai RH, et al. Two new polyacetylenic compounds from Atractylodeschinensis (DC.) Koidz[J]. J Asian Nat Prod Res, 2011, 13(4): 346-349. DOI: 10.1080/ 10286020.2011.557662.

27.Yoshihiro K, Tetsuro S, Ken-ichi K, et al. Polyacetylene compounds from Atractylodes rhizome[J]. Chem Pharm Bull (Tokyo), 1990, 38(4): 1082-1083. DOI: 10.1248/cpb.38.1082.

28.芮梦珏. 橘核、关苍术的化学成分与质量标准研究[D]. 上海: 上海中医药大学, 2021. DOI: 10.27320/d.cnki.gszyu.2019.000082.

29.Nakai Y, Kido T, Hashimoto K, et al. Effect of the rhizomes of Atractylodes lancea and its constituents on the delay of gastric emptying[J]. J Ethnopharmacol, 2003, 84(1): 51-55. DOI: 10.1016/s0378-8741(02)00260-x.

30.Meng H, Li GY, Dai RH, et al. Chemical constituents of Atractylodes chinensis (DC.) Koidz[J]. Biochem Syst Ecol, 2010, 38(6): 1220-1223. DOI: 10.1016/j.bse.2010.12.023.

31.王鹤翔. 茅苍术化学成分、碘催化偶联反应及生物碱Spirotryprostatin B的全合成研究[D]. 兰州: 兰州大学, 2010. DOI: 10.7666/d.Y1705063.

32.Feng ZM, Xu K, Wang W, et al. Two new thiophenepolyacetylene glycosides from Atractylodes lancea[J]. J Asian Nat Prod Res, 2018, 20(6): 531-537. DOI: 10.1080/10286020.2018.1458841.

33.Rui M, Chou G. Three new polyacetylenes from Atractylodes japonica Koidz.ez Kitam[J]. Nat Prod Res, 2022, 36(8): 2063-2070. DOI: 10.1080/14786419.2020. 1845673.

34.Yu C, Xiong Y, Chen D, et al. Ameliorative effects of atractylodin on intestinal inflammation and co-occurring dysmotility in both constipation and diarrhea prominent rats[J]. Korean J Physiol Pharmacol, 2017, 21(1): 1-9. DOI: 10.4196/kjpp.2017.21.1.1.

35.邱伟建, 肖鹏, 吴学建. 苍术素抑制白细胞介素-1β诱导的人骨关节炎软骨细胞炎症[J]. 中华实验外科杂志, 2019, (8): 1442-1444. [Qiu WJ, Xiao P, Wu  XJ. Atractylodes inhibits interleukin-1β-induced chondrocyte inflammation in human osteoarthritis[J]. Chinese Journal of Experimental Surgery, 2019, (8): 1442-1444.] DOI: 10.3760/cma.j.issn.1001-9030.2019.08.032.

36.Tang F, Fan K, Wang K, et al. Atractylodin attenuates lipopolysaccharide-induced acute lung injury by inhibiting NLRP3 inflammasome and TLR4 pathways[J]. J Pharmacol Sci, 2018, 136(4): 203-211. DOI: 10.1016/j.jphs.2017.11.010.

37.Yang L, Ji C, Li Y, et al. Natural potent NAAA inhibitor atractylodin counteracts LPS-induced microglial activation[J]. Front Pharmacol, 2020, 11: 577319. DOI: 10.3389/fphar.2020.577319.

38.Chuang CH, Cheng YC, Lin SC, et al. Atractylodin suppresses dendritic cell maturation and ameliorates collagen-induced arthritis in a mouse model[J]. J Agric Food Chem, 2019, 67(24): 6773-6784. DOI: 10.1021/acs.jafc.9b01163.

39.Qu L, Lin X, Liu C, et al. Atractylodin attenuates dextran sulfate sodium-induced colitis by alleviating gut microbiota dysbiosis and inhibiting inflammatory response through the MAPK pathway[J]. Front Pharmacol, 2021, 12: 665376. DOI: 10.3389/fphar.2021.665376.

40.Jeong SI, Kim SY, Kim SJ, et al. Antibacterial activity of phytochemicals isolated from Atractylodes japonica against methicillin-resistant Staphylococcus aureus[J]. Molecules, 2010, 15(10): 7395-7402. DOI: 10.3390/molecules 15107395.

41.孟令彬. 关苍术提取物及其有效成分的抗菌活性研究[D]. 吉林延吉: 延边大学, 2016. DOI: 10.7666/d.Y3061093.

42.张琳, 朱琳, 李晨. 苍术素调节Notch信号对EGFR-TKI耐药的非小细胞肺癌细胞株H1975增殖、凋亡的影响[J]. 临床肺科杂志, 2023, 28(10): 1487-1493, 1510. [Zhang L, Zhu L, Li C. Effect of atractyloxin-regulated Notch signaling on the proliferation and apoptosis of EGFR-TKI-resistant non-small cell lung cancer cell line H1975[J]. Journal of Clinical Pulmonary Medicine, 2023, 28(10): 1487-1493, 1510.] DOI: 10.3969/j.issn.1009-6663.2023.10.006.

43.Acharya B, Chaijaroenkul W, Na-Bangchang K. Atractylodin inhibited the migration and induced autophagy in cholangiocarcinoma cells via PI3K/AKT/mTOR and p38MAPK signalingpathways[J]. J Pharm Pharmacol, 2021, 73(9): 1191-1200. DOI: 10.1093/jpp/rgab036.

44.He Y, Fang D, Liang T, et al. Atractylodin may induce ferroptosis of human hepatocellular carcinoma cells[J]. Ann Transl Med, 2021, 9(20): 1535. DOI: 10.21037/atm-21-4386.

45.Zhang T, Li SM, Li YN, et al. Atractylodin induces apoptosis and inhibits the migration of A549 lung cancer cells by regulating ROS-mediated signaling pathways[J]. Molecules, 2022, 27(9): 2946. DOI: 10.3390/molecules 27092946.

46.邵晨, 胡建鹏, 严金川, 等. 苍术素对人结肠癌LS174T细胞增殖的影响[J]. 江苏大学学报(医学版), 2016, 26(6): 480-483. [Shao C, Hu JP, Yan JC, et al. Effect of atractylodes on the proliferation of LS174T cells in human colon cancer[J]. Journal of Jiangsu University (Medicine Edition), 2016, 26(6): 480-483.] DOI: 10.13312/j.issn.1671-7783.y160233.

47.Kotawong K, Chaijaroenkul W, Muhamad P, et al. Cytotoxic activities and effects of atractylodin and β-eudesmol on the cell cycle arrest and apoptosis on cholangiocarcinoma cell line[J]. J Pharmacol Sci, 2018, 136(2): 51-56. DOI: 10.1016/j.jphs.2017.09.033.

48.张明发, 沈雅琴. 苍术及其有效成分消化系统药理作用的研究进展[J]. 药物评价研究, 2017, 40(3): 411-419. [Zhang MF, Shen YQ. Research progress on the pharmacological effects of Atractylodes atractylodes and its active ingredients in the digestive system[J]. Drug Evaluation Research, 2017, 40(3): 411-419.] DOI: 10.7501/j.issn.1674-6376.2017.03.025.

49.Bai Y, Zhao YH, Xu JY, et al. Atractylodin induces myosin chain phosphorylation and promotes gastric emptying through grelin receptor[J]. Evid Based Complement Alternat Med, 2017, 2017: 2186798. DOI: 10.1155/2017/2186798.

50.刘芬, 田春漫. 苍术素对脾虚证大鼠胃黏膜超微结构及胃肠功能的影响[J]. 中华中医药杂志, 2016, 31(3): 1002-1005. [Liu F, Tian CM. Effects of atractylodin on ultrastructure of gastric mucosa and gastrointestinal function of rats with syndrome of spleen deficiency[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2016, 31(3): 1002-1005.] DOI: CNKI:SUN:BXYY.0.2016-03-072.

51.高丽, 张文慧, 王羽维, 等. 苍术素对大鼠心脏正性肌力的作用及其机制[J]. 中国应用生理学杂志, 2020, 36(5): 408-413. [Gao L, Zhang WH, Wang  YW, et al. Positive inotropic effect of atractylodin in normal rats and its underlying mechanism[J]. Chinese Journal of Applied Physiology, 2020, 36(5): 408-413.] DOI: 10.12047/j.cjap. 5992.2020.087.

52.Nur EAA, Ohshiro T, Kobayashi K, et al. Inhibition of ch.olesteryl ester synthesis by polyacetylenes from Atractylodes rhizome[J]. Bioorg Med Chem Lett, 2020, 30(7): 126997. DOI: 10.1016/j.bmcl.2020.126997.

53.Kano Y, Komatsu K, Saito K, et al. A new polyacetylene compound from Atractylodes Rhizome[J]. Chem Pharm Bull (Tokyo), 1989, 37(1): 193-194. DOI: 10.1248/cpb.37.193.

54.Chen HP, Zheng LS, Yang K, et al. Insecticidal and repellant activities of polyacetylenes and lactones derived from Atractylodeslancea rhizomes[J]. Chem Biodivers, 2015, 12(4): 593-598. DOI: 10.1002/cbdv.201400161.

55.Choi KH, Jeong SI, Lee JH, et al. Acetylene compound isolated from Atractylodes japonica stimulates the contractility of rat distal colon via inhibiting the nitrergic-purinergic relaxation[J]. J Ethnopharmacol, 2011, 134(1): 104-110. DOI: 10.1016/j.jep.2010.11.059.