Coptis chinensis is the dried rhizome of three species of Ranunculaceae, including Coptis chinensis, Coptis triangular leaves, and Coptis yunensis, which has medicinal value and can dispel dampness, relieve fire and treat dysentery. By consulting ancient books, Coptis chinensis can be processed into different processed products with different functions by using different auxiliary materials to adapt to different clinical conditions. For example, after being processed with ginger, Coptis chinensis becomes cold but not stagnant, thus enhancing its effect of stopping vomiting and dispersing liver and gallbladder fire; processed with Tetradium ruticarpum, Coptis chinensis can clear the damp heat in the layer and soothe the stomach and liver.A systematic review revealed that the 2020 version of the Pharmacopoeia of the People's Republic of China and many local processing standards include the wine processed Coptidis, turmeric processed Copidis, and Yuhuanglian processed Copidis, while the bile processed Copidis is a recent research hotspot, and a more detailed summary of the bile processed Copidis is conducted in this paper. Due to the unclear indicative components and pharmacological action mechanisms of the various processed products of Coptis chinensis, the production and clinical application of these products are limited. This review summarizes and integrates the historical processing, process research, chemical component differences, and pharmacological effects of Coptis chinensis processed products to improve the quality evaluation system of these products and provide theoretical basis for elucidating their processing principles.

1.中国药典2020年版. 一部[S]. 2020: 316.

2.南北朝·雷敩, 编撰. 雷公炮炙论[M]. 合肥: 安徽科学技术出版社, 1991: 228-230.

3.元·罗天益, 编撰. 卫生宝鉴[M]. 海口: 海南国际新闻出版中心, 1995: 324-326.

4.明·朱橚, 滕硕, 刘醇, 编撰. 普济方[M]. 上海: 上海古籍出版社, 1991: 225.

5.明·龚廷贤, 撰著. 寿世保元[M]. 北京: 中国中医药出版社, 2021: 218-221.

6.《域外中医古籍丛书》编委会, 主编. 本草述[M]. 北京: 线装书局, 2017: 146-148.

7.明·董宿, 辑录. 奇效良方[M]. 北京: 中国中医药出版社, 1995: 325-326.

8.明·张介宾, 撰. 景岳全书[M]. 天津: 天津科学技术出版社, 2015: 126-128.

9.清·陈修园, 著.时方妙用[M]. 福州: 福建科学技术出版社, 2019: 256.

10.清·赵学敏, 编著. 串雅内编[M]. 北京: 人民军医电子出版社, 2011: 128.

11.明·薛铠, 撰.保婴撮要[M]. 北京: 中国中医药出版社, 2016: 366-367.

12.明·鲁伯嗣, 著.婴童百问[M]. 北京: 中版集团数字传媒有限公司, 2021: 421-425.

13.北宋·唐慎微, 著. 证类本草[M]. 上海: 上海古籍出版社, 1991: 532-531.

14.明·兰茂, 著. 滇南本草[M]. 北京: 中国中医药出版社, 2013: 544.

15.宋·史堪, 著.史载之方[M]. 上海: 上海科学技术出版社, 2003: 471.

16.宋·洪遵, 撰. 洪氏集验方[M]. 北京: 线装书局, 2017: 122-124.

17.故宫博物院, 主编. 修事指南[M]. 海口: 海南出版社, 2000: 225.

18.明·楼英, 编. 医学纲目[M]. 上海: 上海科学技术出版社, 2000: 351.

19.汉·刘若金, 著. 本草述钩元三十二卷[M]. 北京: 北京出版社, 2000: 566.

20.清·洪正立, 编. 医学入门万病衡要[M]. 北京: 中医古籍出版社, 2015: 452-456.

21.王德珍, 易骏, 张翼, 等. 酒黄连、姜黄连、萸黄连最佳炮制工艺研究[J]. 中药材, 2013, 36(1): 35-37. [Wang DZ, Yi J, Zhang Y, et al. Study on optimal processing technology of three kinds of processed Coptidis rhizoma[J]. Journal of Chinese Medicinal Materials, 2013, 36(1): 35-37.] DOI: 10.13863/j.issn1001-4454.2013.01.017.

22.范刚, 郑海杰, 赖先荣, 等. 基于改善胰岛素抵抗活性和有效成分含量的酒蒸黄连炮制工艺优选[J]. 中国实验方剂学杂志, 2014, 20(4): 5-8. [Fan G, Zheng HJ, Lai  XR, et al. Optimization of processing technology for Coptidis rhizoma steamed with rice wine based on improvement of insulin resistance activity and contents of effective ingredients[J]. Chinese Journal of Experimental Traditional Medical Formulae[J]. 2014, 20(4): 5-8.] DOI: 10.11653/syfj2014040005.

23.王邸泽昭, 韩平欣, 孙思侨, 等. 吴茱萸炒黄连的炮制工艺及其指纹图谱分析[J]. 时珍国医国药, 2021, 32(10): 2417-2420. [Wang DZZ, Han PX, Sun SQ, et al. Processing process and fingerprint analysis of fried Coptis chinensis from Evodia officinalis[J]. Lishizhen Medicine and Materia Medica Research, 2021, 32(10): 2417-2420.] DOI: 10.3969/j.issn.1008-0805.2021.10.28．

24.张崇佩, 龚千锋, 于欢, 等. 樟帮特色黄连水炒吴茱萸炮制工艺研究[J]. 中草药, 2019, 50(13): 3065-3070. [Zhang CP, Gong QF, Yu H, et al. Study on processing technology of stir-fried Euodiae Fructus with water decoction of Coptidis rhizoma of Zhangbang[J]. Chinese Traditional and Herbal Drugs, 2019, 50(13): 3065-3070.] DOI: 10.7501/j.issn.0253-2670.2019.13.011.

25.文小女, 钟凌云. 正交试验优选樟帮姜黄连的炮制工艺[J]. 中国实验方剂学杂志, 2016, 22(15): 18-20. [Wen  XN, Zhong LY. Optimization of processing technology of Zhangbang ginger juice processed Coptidis rhizoma by orthogonal test[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2016, 22(15): 18-20.] DOI: 10.13422/j.cnki.syfjx.2016150018.

26.王鑫. 黄连、姜黄连的炮制工艺及质量控制研究[D]. 北京: 北京中医药大学, 2018. DOI: 10.26973/d.cnki.gbjzu.2018.000233.

27.上海市卫生局. 上海市中药饮片炮制规范[S]. 2019: 246 .

28.王静, 陈悦, 袁子民, 等. 响应面法优化胆黄连的炮制工艺[J]. 中华中医药学刊, 2015, 33(6): 1298-1300. [Wang J, Chen Y, Yuan ZM, et al. Optimization of processing technology of bile processed Rhizoma coptidis using response surface methodology[J]. Chinese Archives of Traditional Chinese Medicine, 2015, 33(6): 1298-1300.] DOI: 10.13193/j.issn.1673-7717.2015.06.004.

29.王苗苗, 周雅倩, 顾淯, 等. 中药特色临方炮制品种挖掘—胆黄连饮片的炮制工艺及质量标准研究[J]. 中草药, 2023, 54(22): 7421-7428. [Wang MM, Zhou YQ, Gu Y, et al. Processing technology and quality standard of bile processed Coptidis rhizoma decoction pieces-excavating processing varieties of Chinese medicine characteristic clinical prescription[J]. Chinese Traditional and Herbal Drugs, 2023, 54(22): 7421-7428.] DOI: 10.7501/j.issn.0253-2670.2023.22.018.

30.周霞, 杨诗龙, 胥敏, 等. 电子舌技术鉴别黄连及其炮制品[J]. 中成药, 2015, 37(9): 1993-1997. [Zhou X, Yang SL, Xu M, et al. Discrimination of Coptis chinensis Franch and its processed products by electronic tongue[J]. Chinese Traditional Patent Medicine, 2015, 37(9): 1993-1997.] DOI: 10.3969/j.issn.1001-1528.2015.09.027.

31.胥敏, 杨诗龙, 张超, 等. 基于气味客观化的黄连及其炮制品鉴别研究[J]. 中国中药杂志, 2015, 40(1): 89-93.[Xu M, Yang SL, Zhang C, et al. Discrimination of Coptidis rhizoma and its processed products by odor objectify[J]. China Journal of Chinese Materia Medica, 2015, 40(1): 89-93.] DOI: 10.4268/cjcmm20150117.

32.陈高源, 韩一凡, 韩羽亭, 等. “酒制升提”炮制理论在“寒性”中药中的应用及研究进展[J]. 湖北中医药大学学报, 2024, 26(4): 120-124. [Chen GY, Han  YF, Han YT, et al. Application and research progress of the processing theory of "wine processing for uplifting" in "cold" Chinese medicine[J]. Journal of Hubei University of Chinese Medicine, 2024, 26(4): 120-124.] DOI: 10.3969/j.issn.1008-987x.2024.04.34.

33.杨念云, 张启春, 朱华旭, 等. 黄连生物碱类资源性化学成分研究进展与利用策略[J]. 中草药, 2019, 50(20): 5080-5087. [Yang NY, Zhang QC, Zhu HX, et al. Research progress and utilization strategy on alkaloid resource chemistry of Coptidis rhizoma[J]. Chinese Traditional and Herbal Drugs, 2019, 50(20): 5080-5087.]DOI: 10.7501/j.issn.0253-2670.2019.20.034.

34.Gu SG, Song XH, Xie RF, et al. Berberine inhibits cancer cells growth by suppressing fatty acid synthesis and biogenesis of extracellular vesicles[J]. Life Sci, 2020, 257: 118122. DOI: 10.1016/j.lfs.2020.118122.

35.王钰乐, 张建锋, 杨道斌, 等. 戊己丸中黄连-白芍药对的UPLC-MS/MS指纹图谱研究[J]. 时珍国医国药, 2016, 27(10): 2332-2335. [Wang YL, Zhang JF, Yang DB, et al. UPLC-MS/MS fingerprinting study of Coptis chinensis-Paeonia alba pair in Pentecostan pills[J]. Lishizhen Medicine and Materia Medica Research, 2016, 27(10): 2332-2335.] DOI: 10.3969/j.issn.1008-0805. 2016.10.009.

36.王旭华, 徐顶巧, 陈艳琰, 等. 基于层次分析法及多指标正交试验优选黄连-吴茱萸药对提取工艺[J]. 中药材, 2022, 45(8): 1935-1938. [Wang XH, Xu DQ, Chen YY, et al. Optimization of extraction process of coptidis Rhizoma-Euodiae Fructus based on analytic hierarchy process and multi-index orthogonal test[J]. Journal of Chinese Medicinal Materials, 2022, 45(8): 1935-1938.] DOI: 10.13863/j.issn1001-4454.2022.08.028.

37.马嘉仪, 杨琰, 张竞研, 等. 基于UPLC-Q-TOF-MS/MS技术分析香连丸的化学成分与小鼠体内的入血成分及代谢产物[J]. 南京中医药大学学报, 2024(5): 510-520. [Ma JY, Yang Y, Zhang JY, et al. Based on UPLC-Q-TOF-MS/MS technology, the chemical composition of Xianglian pill and the blood components and metabolites in mice were analyzed[J]. Journal of Nanjing University of Traditional Chinese Medicine, 2024(5): 510-520.] DOI: 10.14148/j.issn.1672-0482.2024.0510.

38.赵文燕, 向茜, 王蝉, 等. 基于UPLC-Q-TOF/MS和模式识别技术阐释樟帮特色黄连水炒吴茱萸的炮制科学内涵[J]. 中国实验方剂学杂志, 2022, 28(21): 147-155. [Zhao WY, Xiang Q, Wang C, et al. Explanation of scientific connotation of Euodiae fructus stir-fried with Coptidis rhizoma based on UPLC-Q-TOF/MS and pattern recognition technology[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2022, 28(21): 147-155.]DOI: 10.13422/j.cnki.syfjx.20220147.

39.陈冬玲, 张凯, 于欣羽, 等. 基于UPLC-LTQ-Orbitrap/MS的姜黄连炮制前后化学成分比较研究[J]. 药物评价研究, 2022, 45(4): 693-701. [Chen DL, Zhang K, Yu  XY, et al. A comparative study on chemical constituents of Coptidis rhizoma processed with fresh ginger juice before and after processing based on UPLC-LTQOrbitrap/MS[J]. Drug Evaluation Research, 2022, 45(4): 693-701.] DOI: 10.7501/j.issn.1674-6376.2022.04.012.

40.白而力. 不同辅料炮制对黄连生物碱类成分含量的影响[J]. 亚太传统医药, 2016, 12(13): 38-39. [Bai EL. Effects of different excipients on the content of alkaloids in Coptis chinensis[J]. Asia-Pacific Traditional Medicine, 2016, 12(13): 38-39.] DOI: 10.11954/ytctyy.201613017.

41.蒋丽施, 李潇彧, 罗曦, 等. 黄连的研究进展及其质量标志物预测分析[J]. 中华中医药学刊, 2023, 41(8): 97-109. [Jiang LS, Li XY, Luo X, et al. Research progress of Coptidis rhizoma and predictive analysis on quality markers[J]. Chinese Archives of Traditional Chinese Medicine, 2023, 41(8): 97-109.] DOI: 10.13193/j.issn.1673-7717.2023.08.021.

42.王静, 吕佳, 袁子民, 等. 猪胆汁炮制对黄连中生物碱类成分溶出的影响[J]. 中国实验方剂学杂志, 2016, 22(5): 5-8. [Wang J, Lyu J, Yuan ZM, et al. Effect of being processed on dissolution of alkaloids in Coptidis rhizoma with pig's bile[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2016, 22(5): 5-8.] DOI: 10.13422/j.cnki.syfjx.2016050005.

43.贠亚波, 臧琛, 郭凤倩, 等. 辅料姜汁对黄连生物碱成分的影响[J]. 中国中医药信息杂志, 2019, 26(5): 69-72.[Yuan YB, Zang C, Guo FQ, et al. Effects of adjuvant ginger juice on alkaloids of Coptidis rhizoma[J]. Chinese Journal of Traditional Chinese Medicine Information, 2019, 26(5): 69-72.] DOI: 10.3969/j.issn.1005-5304.2019.05.015.

44.郭玲燕, 魏永利, 吴芳, 等. 酒制黄连的研究进展[J]. 中国药房, 2019, 30(22): 3164-3168. [Guo LY, Wei YL, Wu F, et al. Research progress on the production of Coptis chinensis[J]. Chinese Pharmacy, 2019, 30(22): 3164-3168.] DOI: 10.6039/j.issn.1001-0408.2019.22.28.

45.时晓媞. 川产黄连及其炮制品降糖化学成分与药效研究[D]. 成都: 西南交通大学, 2017. https://cdmd.cnki.com.cn/Article/CDMD-10613-1017137235.htm.

46.王静, 郭鑫, 陈雪莲, 等. 外翻肠囊法研究黄连与胆黄连中生物碱类成分的吸收差异[J]. 时珍国医国药, 2023, 34(5): 1097-1101. [Wang J, Guo X, Chen XL, et al. The intestinal sac method was used to study the difference in the absorption of alkaloids in Coptis chinensis and Coptis biliformis[J]. Lishizhen medicine and materia medica research, 2023, 34(5): 1097-1101.] DOI: 10.3969/j.issn.1008.0805.2023.05.19.

47.石艳红. 不同炮制对部分中药微量元素的影响[J]. 中国医药指南, 2013, 11(4): 103-104. [Shi YH. Effects of different processing on trace elements in some traditional Chinese medicines[J]. Guide of China Medicine, 2013, 11(4): 103-104.] DOI: 10.15912/j.cnki.gocm.2013.04.062.

48.Cui LJ, Liu M, Chang XY, et al. The inhibiting effect of the Coptis chinensisi polysaccharide on the type II diabetic mice[J]. Biomed Pharmacother, 2016, 81: 111-119. DOI: 10.1016/j.2016.03.038.

49.薛明松, 郑玉玉, 张宇峰, 等. 黄连粗多糖协同小檗碱改善溃疡性结肠炎肠黏膜屏障损伤的作用[J]. 中国实验方剂学杂志, 2022, 28(13): 71-76. [Xue MS, Zheng YY, Zhang YF, et al. Coptidis rhizoma crude polysaccharide and berberine synergistically restore intestinal mucosal barrier damage in Ulcerative colitis[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2022, 28(13): 71-76.] DOI: 10.13422/j.cnki.syfjx.20220702.

50.吉文岳, 冯心池, 邱峰, 等. 黄连多糖药理作用研究进展[J]. 药物评价研究, 2021, 44(3): 638-643. [Ji WY, Feng  XC, Qiu F, et al. Research progress on pharmacological effects of Coptis chinensis polysaccharide[J]. Drug Evaluation Research, 2021, 44(3): 638-643.] DOI: 10.7501/j.issn.1674-6376.2021.03.027.

51.周东月. 黄连多糖对糖尿病大鼠肾脏损伤的保护作用及机制研究[D].长春: 长春中医药大学, 2020. DOI: 10.26980/d.cnki.gcczc.2020.000241.

52.周东月, 王春璐, 任艳平, 等. 黄连多糖通过抑制氧化应激和炎症反应减轻糖尿病大鼠肾损伤的实验研究 [J]. 中国比较医学杂志, 2019, 29(3): 37-42. [Zhou DY, Wang  CL, Ren YP, et al. Coptis chinensis polysaccharide protects against renal injury in diabetic rats by suppressing oxidative stress and inflammation reaction[J]. Chinese Journal of Comparative Medicine, 2019, 29(3): 37-42.] DOI: 10.3969/jissn1671-7856.2019.03.006.

53.Zhou LM, Fan JH, Xu MM, et al. Epiberberine regulates lipid synthesis through SHP (NR0B2) to improve non-alcoholic steatohepatitis[J]. Biochim Biophys Acta Mol Basis Dis, 2023, 1869(4): 166639. DOI: 10.1016/j.bbadis.2023.166639.

54.Qi LM, Zhong FR, Liu NN, et al. Characterization of the anti-AChE potential and alkaloids in Rhizoma coptidis from different Coptis species combined with spectrum-effect relationship and molecular docking[J]. Front Plant Sci, 2022, 13: 1020309. DOI: 10.3389/fpls.2022.1020309.

55.Wong LR, Tan EA, Lim MEJ,et al. Functional effects of berberine in modulating mitochondrial dysfunction and inflammatory response in the respective amyloidogenic cells and activated microglial cells In vitro models simulating Alzheimer's disease pathology[J]. Life Sci, 2021, 282: 119824. DOI: 10.1016/j.lfs.2021.119824.

56.Li YJ, Wang BM, Liu C, et al. Inhibiting c-Jun N-terminal kinase (JNK)-mediated apoptotic signaling pathway in PC12 cells by a polysaccharide (CCP) from Coptis chinensis against amyloid-β (Aβ)-induced neurotoxicity[J]. Int J Biol Macromol, 2019, 134: 565-574. DOI: 10.1016/j.ijbiomac.2019.05.041.

57.Wang J, Wu SN, Gao H, et al. Integrated metabolomics and network pharmacology analysis to explore pig bile-processed Rhizoma coptidis and Fructus evodiae sauce-processed Rhizoma coptidis in lipopolysaccharide-induced inflammatory response[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2024, 1243: 124192. DOI: 10.1016/j.jchromb.2024.124192.

58.Li JS, Hou XL, Xiao JL, et al. Synthesis of new derivatives of berberine canagliflozin and study of their antibacterial activity and mechanism[J]. Molecules, 2024, 29(1): 273. DOI: 10.3390/molecules29010273.

59.Song T, Chen WD. Berberine inhibited carotid atherosclerosis through PI3K/AKTmTOR signaling pathway[J]. Bioengineered, 2021, 12(1): 8135-8146. DOI:10.1080/21655979.2021.1987130.

60.邓玉芬, 钟凌云. 大鼠舌象扫描电镜探究不同姜汁制黄连的差异性[J].中国实验方剂学杂志, 2016, 22(1): 6-9. [Deng YF, Zhong LY. Explore differences in Coptidis rhizome processed with different ginger juice by tongue scanning electron microscopy in rats[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2016, 22(1): 6-9.] DOI: 10.13422/j.cnki.syfjx.2016010006.

61.邓玉芬, 钟凌云, 孟振豪. 基于大鼠宏观行为观察的不同姜汁对黄连寒热药性的影响研究[J]. 世界科学技术-中医药现代化, 2016, 18(3): 516-521. [Deng  YF, Zhong LY, Meng ZH, et al. Study on the effects of different ginger juice on the medicinal properties of Coptis chinensis based on macroscopic behavior observation in rats[J]. World Science and Technology-Modernization of Traditional Chinese Medicine, 2016, 18(3): 516-521.] DOI: 10.11842/wst.2016.03.030.

62.陈旭, 周游, 刘琳, 等. 黄连-干姜对糖尿病大鼠脑脊液中主要生物标志物动态变化干预作用的研究[J]. 中南药学, 2022, 20(4): 799-804. [Chen X, Zhou Y, Liu L, et al. Effect of coptis-dried ginger on the dynamic changes of main biomarkers in the cerebrospinal fluid of diabetic rats[J]. Central South Pharmacy, 2022, 20(4): 799-804.]DOI: 10.7539/j.issn.1672-2981.2022.04.012.

63.时晓媞, 吴晓青, 任瑶瑶,等. 川黄连不同炮制品改善四氧嘧啶小鼠糖及脂代谢紊乱比较研究[J]. 世界科学技术-中医药现代化A, 2019, 21(8): 1634-1641. [Shi XT, Wu XQ, Ren YY, et al. comparative study on the improvement of glucose and lipid metabolism disorders in alloxan mice with different processed products of Coptis chuanhuanglian[J]. World Science and Technology-Modernization of Traditional Chinese Medicine, 2019, 21(8): 1634-1641.] DOI: 10.11842/wst.20190306005.

64.王瑾, 冉倩, 王琳,等. 基于16S rRNA技术分析黄连酒蒸前后对正常及2型糖尿病大鼠肠道微生物的影响[J]. 中国实验方剂学杂志, 2019, 25(22): 92-102.[Wang J, Ran Q, Wang L, et al. Effect of Coptidis rhizoma on gut microbiota of normal and type 2 diabetic rats before and after being steamed with rice wine based on 16S rRNA technique[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2019, 25(22): 92-102.] DOI: 10.13422/j.cnki.syfjx.20192447.

65.刘瑞丰, 吕建东, 张晓鹏,等. 茱萸丸对大鼠实验性2型糖尿病的治疗作用[J]. 中国实验方剂学杂志, 2011, 17(17): 154-157. [Liu RF, Lyv JD, Zhang XP, et al. Therapeutical effect of Zhuyu Wan on type 2 diabetes in rats[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2011, 17(17): 154-157.] DOI: 10.13422/j.cnki.syfjx.2011.17.059.

66.钟凌云, 王婷婷, 徐婷. “谱-效-性”关联分析探讨不同姜汁炮制黄连的作用差异谱-效-性”关联分析探讨不同姜汁炮[J]. 中国实验方剂学杂志, 2018, 24(20): 7-13. [Zhong LY, Wang TT, Xu T, et al. Different effect between Coptidis rhizoma processed with different ginger juice based on correlation analysis of fingerprint-pharmacological effect-drug property[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2018, 24(20): 7-13.] DOI: 10.13422/j.cnki.syfjx.20181801.

67.杨伟鹏, 王怡薇, 王彦礼, 等. 吴茱萸汁炮制对黄连抗炎药效和苦寒药性的影响[J]. 中国中医药信息杂志, 2013, 20(8): 42-44. [Yang WP, Wang YW, Wang YL, et al.Effect of evodia juice on the anti-inflammatory efficacy and bitter cold medicinal properties of coptis chinensis[J]. Chinese Journal of Information on TCM, 2013, 20(8): 42-44.] DOI: 10.3969/j.issn.1005-5304.2013.08.015.

68.张振凯, 郑亚娟, 张冰贤, 等. 黄连及其炮制品对实热型口腔溃疡大鼠干预作用的代谢组学研究[J]. 中国中药杂志, 2024, 49(2): 389-402. [Zhang ZK, Zheng YJ, Zhang BX, et al. Metabolomics study of the intervention effect of Coptis chinensis and its processed products on rats with hot oral ulcers[J]. China Journal of Chinese Materia Medica, 2024, 49(2): 389-402.] DOI: 10.19540/j.cnki.cjcmm.20231030.302.

69.赵文燕, 向茜, 王蝉, 等. UPLC-Q-TOF-MS联合网络药理学和实验验证分析黄连水炒吴茱萸治疗慢性结肠炎的作用机制[J]. 中国中药杂志, 2022, 47(19): 5316-5326. [Zhao WY, Xiang Q, Wang C, et al. Mechanism of Euodiae fructus stir-fried with water decoction of Coptidis rhizoma in treatment of chronic colitis based on UPLC-Q-TOF-MS, network pharmacology and experimental verification[J]. China Journal of Chinese Materia Medica, 2022, 47(19): 5316-5326.] DOI: 10.19540/j.cnki.cjcmm.20220314.402.

70.Chen SY, Chen ZJ, Wang Y, et al. Targeted delivery of Chinese herb pair-based berberine/tannin acid self-assemblies for the treatment of ulcerative colitis[J]. J Adv Res, 2022, 40: 263-276. DOI: 10.1016/j.jare.2021.11.017.

71.余玲. “黄连-干姜”药对用于治疗溃疡性结肠炎研究进展[J]. 亚太传统医药, 2022, 18(11): 230-235. [Yu L. Research progress on the use of "Coptis chinensis-Ginger" drug for the treatment of ulcerative colitis[J]. Asia-Pacific Traditional Medicine, 2022, 18(11): 230-235.] DOI: 10.11954/ytxtyy.202211045.

72.刘霜, 旺建伟. 左金丸及其主要单体成分抗结直肠癌机制的研究进展[J]. 中国实验方剂学杂志, 2023, 29(22): 204-214. [Liu S, Wang JW. Anti-colorectal cancer mechanism of Zuojinwan and its main monomer components[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2023, 29(22): 204-214.] DOI: 10.13422/j.cnki.syfjx.20232225.

73.余蕾, 谢晓芳, 彭芙,等. 香连丸水提物和醇提物对5-FU致小鼠肠黏膜损伤保护作用的比较[J]. 中成药, 2024, 46(4): 1322-1326. [Yu L, Xie XF, Peng  F, et al. Comparison of the protective effects of aqueous and alcohol extracts of Xianglian pills on 5-FU-induced intestinal mucosal injury in mice[J]. Chinese Traditional Patent Medicine, 2024, 46(4): 1322-1326.] DOI: 10.3969/jissn.1001-1528.2024.04.041.

74.张潇, 张亚丽, 苗祥贞,等. 黄连不同炮制品及组分的抗肿瘤活性与6种生物碱含量相关性研究[J]. 中华中医药杂志, 2019, 34(6): 2668-2671. [Zhang X, Zhang  YL, Miao XZ, et al. Study on the correlation of antitumor activity and the content 6 alkaloids of different processed products and components of Rhizoma coptidis based on Caenorhabditis elegans[J]. Chinese Journal of Traditional Chinese Medicine, 2019, 34(6): 2668-2671.] DOI: CNKI:SUN:BXYY.0.2019-06-091.

75.谭朝丹, 楼冰, 顾伟鹰, 等. 不同比例黄连-吴茱萸配方颗粒/单/合煎对比分析[J]. 中国医院药学杂志, 2020, 40(21): 2238-2242. [Tan CD, Lou B, Gu WY, et al. Comparative analysis of different proportions of Coptis chinensis-Evodia formula granules/single/combined decoction[J]. Chinese Journal of Hospital Pharmacy, 2020, 40(21): 2238-2242.] DOI: 10.13286/j.1001-5213.2020.21.06.

76.吴佳栩, 江锋, 匡子禹, 等. 左金丸加味联合西药治疗幽门螺杆菌感染的Meta分析[J]. 湖北中医药大学学报, 2020, 22(6): 122-126. [Wu JX, Jiang F, Kuang ZY, et al. Meta-analysis of Zuojin pill plus western medicine in treatment of Helicobacter Pylori Infection[J]. Journal of Hubei University of Traditional Chinese Medicine, 2020, 22(6): 122-126.] DOI: 10.3969/j.issn.1008-987x.2020.06.34.

77.黄捷. 香连丸联合四联疗法治疗幽门螺杆菌感染的临床疗效分析[J]. 中外医疗, 2022, 41(11): 84-87. [Huang J. Analysis of the clinical efficacy of Xianglian pill combined with quadruple therapy in the treatment of Helicobacter pylori infection[J]. China Foreign Medical Treatment, 2022, 41(11): 84-87.] DOI: 10.16662/j.cnki.1674-0742.2022.11.084.

78.凌成军, 陆雯雯, 郭艳敏, 等. 加味左金丸联合雷贝拉唑治疗胃食管反流病的疗效观察[J]. 现代药物与临床, 2024, 39(1): 167-171. [Ling CJ, Lu WW, Guo YM, et al. Clinical observation of Jiawei Zuojin Pills combined with rabeprazole in treatment of gastroesophageal reflux disease[J]. Drugs & Clinic, 2024, 39(1): 167-171.] DOI: 10.7501/j.issn.1674-5515.2024.01.026.

79.李娜, 殷燕. 胃食管反流病应用加味左金丸联合富马酸伏诺拉生片治疗的临床观察[J]. 内蒙古中医药, 2024, 43(2): 24-26. [Li N, Yin Y. Clinical observation of gastroesophageal reflux disease in the treatment of Jiawei Zuojin pills combined with vonora fumarate raw tablets[J]. Nei Mongol Journal of Traditional Chinese Medicine, 2024, 43(2): 24-26.] DOI: 10.16040/j.cnki.cn15-1101.2024.02.026.

80.鲍亦晨, 尹天雷. 香连丸联合美沙拉嗪治疗湿热蕴结型克罗恩病的临床研究[J]. 中国医学创新, 2022, 19(2): 155-159. [Bao YC, Yin TL. Clinical study of Xianglian pills combined with mesalazine in the treatment of damp-heat accumulation Crohn's disease[J]. Medical Innovation of China, 2022, 19(2): 155-159.] DOI: 10.3969/j.issn.1674-4985.2022.02.039.