Objective  To clarify the efficacy of Linggui Zhugan formula combined with food restriction therapy on patients with metabolic syndrome (MS) of spleen deficiency and dampness obstruction type.

Methods  The clinical data of patients with MS of spleen deficiency and dampness obstruction type who were admitted to Wenzhou TCM Hospital of Zhejiang Chinese Medical University from February 2023 to June 2024 were analyzed. According to the treatment regimens, the enrolled patients were divided into the control group (conventional Western medicine treatment), the food restriction group (conventional Western medicine treatment combined with food restriction therapy), Linggui Shugan formula treatment group (conventional Western medicine treatment combined with Linggui Shugan formula treatment) and the combined group (conventional Western medicine treatment combined with Linggui Shugan formula and food restriction therapy treatment). The traditional Chinese medicine (TCM) syndrome scores, obesity, blood glucose and blood lipid indexes were compared among the four groups before and after treatment. Compare the occurrence of adverse reactions during treatment.

Results  A total of 82 patients were enrolled, including 20 in the control group, 20 in the food restriction group, 21 in the Linggui Shugan formula treatment group, and 21 in the combined group. Compared those with before treatment, the scores of TCM syndromes, such as chest tightness and epigastric plumpness, fatigue and drowsiness, and obesity, and the levels of fasting blood glucose (FBG), fasting insulin (FINS), glycosylated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (ApoB) in the four groups of patients were all decreased (P<0.05). The above indexes in the combined group were significantly lower than those in the control group, the food restriction group and Linggui Zhugan formula treatment group (P<0.05), the above indexes were significantly lower in the food restriction group and Linggui Zhugan Formula treatment group than those in the control group (P<0.05), and no significant differences were exhibited between the food restriction group and the Linggui Zhugan Formula treatment group (P>0.05). The waist circumference, hip circumference and body mass index (BMI) in the four groups were lower compared to before treatment, but the differences were not statistically significant (P>0.05). During the treatment period, no significant adverse reactions occurred in all four groups.

Conclusion  The effect of Linggui Zhugan formula combined with food restriction therapy in the treatment of patients with MS of spleen deficiency and dampness obstruction type is significant. It can significantly alleviate clinical symptoms such as chest tightness and epigastric plumpness, fatigue and drowsiness, and improve the glucolipid metabolism.

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