Objective  To observe the application effect of combination of butylphthalide and programmed intervention on patients with cerebrovascular disease (CVD)-induced hemiplegia.

Methods  Patients with CVD-induced hemiplegia in Zhejiang Provincial People's Hospital were recruited from September 2022 to September 2024, and were divided into the observation group (programmed intervention) and the control group (conventional intervention) by means of the random number table method in a 1 ∶ 1 ratio, both of which were intervened for 3 months. At the same time, two groups were treated with butylphthalide for 14 days and rehabilitated with exercise for 3 months. The compliance of the two groups of patients during intervention was evaluated at 3 months of intervention. The neurological function [National Institutes of Health Stroke Scale (NIHSS)], motor ability [grip strength, upper and lower limb muscle strengths, Fugl-Meyer motor assessment (FMA)], self-care ability [modified Barthel index (MBI)] were evaluated in the two groups before intervention and at 14 days and 3 months of intervention, and the occurrence of the adverse events during intervention were counted.

Results  A total of 100 patients were recruited, with 50 in each group. The compliance in the observation group was higher than that in the control group during 3 months of intervention (P<0.05). The NIHSS scores in two groups at 14 days and 3 months of intervention were decreased while the grip strength, upper and lower limb muscle strengths, FMA scores and MBI scores were increased (P<0.05). At 14 days of intervention, there were no significant difference in NIHSS scores and MBI scores between groups (P>0.05), but the grip strength, upper and lower limb muscle strengths and FMA score were higher in the observation group (P<0.05). No significant difference was exhibited in the comparison of NIHSS scores between the groups at 3 months of intervention (P>0.05), but MBI score, grip strength, upper and lower limb muscle strengths and FMA score in the observation group were higher (P<0.05). The total incidence rate of adverse events in the observation group during 3 months of intervention was lower compared to the control group (P<0.05).

Conclusion  The combination of butylphthalide and programmed intervention can improve motor function and life ability in the short term, and reduce the risk of adverse events..

1.冯秀群, 刘丽妍, 黎小然, 等. 早期康复措施在急性脑血管病偏瘫患者中的应用效果分析[J]. 山西医药杂志, 2020, 49(2): 204-206. [Feng XQ, Liu LY, Li XR, et al. Analysis of the effect of early rehabilitation measures in patients with acute cerebrovascular disease hemiplegia[J]. Shanxi Medical Journal, 2020, 49(2): 204-206.] DOI: 10.3969/j.issn.0253-9926.2020.02.033.

2.刘博会, 焦慧娟, 刘俊平, 等. 丁苯酞对急性脑梗死患者血管内皮功能和神经功能的改善[J]. 西北药学杂志, 2024, 39(3): 100-104. [Liu BH, Jiao HJ, Liu JP, et al. Improvement of vascular endothelial function and neurological function in patients with acute cerebral infarction treated with butylphthalide[J]. Northwest Pharmaceutical Journal, 2024, 39(3): 100-104.] DOI: 10.3969/j.issn.1004-2407.2024.03.017.

3.张晶晶, 杨超, 田珊珊. 丁苯酞联合长春西汀注射液对老年高血压合并急性脑梗死患者的神经炎症反应及认知功能的影响[J]. 药物生物技术, 2024, 31(3): 260-265. [Zhang JJ, Yang  C, Tian SS. Effects of butylphthalein combined with vinpocetine injection on neuroin-flammatory response and cognitive function in elderly hypertension patients complicated with acute cerebral infarction[J]. Pharmaceutical Biotechnology, 2024, 31(3): 260-265.] DOI: 10.19526/j.cnki.1005-8915.20240308.

4.刘冠雄, 朱风俊, 徐明超, 等. 曲克芦丁联合丁苯酞治疗脑梗死的临床疗效评价[J]. 数理医药学杂志, 2023, 36(5): 370-376. [Liu GX, Zhu FJ, Xu MC, et al. Clinical efficacy evaluation of troxerutin combined with butylphthalide in the treatment of cerebral infarction[J]. Journal of Mathematical Medicine, 2023, 36(5): 370-376.] DOI: 10.12173/j.issn.1004-5511.202303178.

5.邱锦芳, 郭峰, 林军. 强制性运动疗法联合丁苯酞对老年脑梗死恢复期患者上肢运动功能、认知功能和日常生活能力的影响[J]. 临床与病理杂志, 2022, 42(12): 2918-2924. [Qiu JF, Guo F, Lin J. Effect of constraint-induced movement therapy combined with butylphthalide on limb motor function,cognitive function and daily living ability of elderly patients with cerebral infarction in recovery period[J]. Journal of Clinical and Pathology, 2022, 42(12): 2918-2924.] DOI: 10.3978/j.issn.2095-6959.2022.12.009.

6.顾伟, 朱正萍, 陈玉兰, 等. 丁苯酞治疗急性缺血性脑卒中的效果及对血清因子的影响[J]. 中国医药导报, 2022, 19(5): 86-88, 92. [Gu W, Zhu ZP, Chen YL, et al. Effect of butylphthalide in the treatment of acute ischemic stroke and its influence on serum factors[J]. China Medical Herald, 2022, 19(5): 86-88, 92.] https://www.yiyaodaobao.com.cn/CN/Y2022/V19/I5/86.

7.肖芝花, 黄燕, 张芳, 等. 基于最佳证据总结的康复护理在脑卒中偏瘫患者中的应用[J]. 护理实践与研究, 2024, 21(4): 489-496. [Xiao ZH, Huang Y, Zhang F, et al. Application of rehabilitation nursing based on the best evidence summary in patients with hemiplegia after stroke[J]. Nursing Practice and Research, 2024, 21(4): 489-496.] DOI: 10.3969/j.issn.1672-9676.2024.04.003.

8.李淑玲, 王静蓉, 张小红, 等. 基于HBM理念的程序化护理方案在甲状腺肿瘤患者微波消融围术期中的应用[J]. 护理实践与研究, 2024, 21(2): 274-280. [Li SL, Wang JR, Zhang  XH, et al. Application of programmed nursing plan based on HBM concept in the perioperative period of microwave ablation for thyroid tumor patients[J]. Nursing Practice and Research, 2024, 21(2): 274-280.] DOI: 10.3969/j.issn.1672-9676.2024.02.019.

9.中华医学会神经病学分会中华医学会神经病学分会脑血管病学组. 中国各类主要脑血管病诊断要点2019[J]. 中华神经科杂志, 2019, 52(9): 710-715. [Chinese Society of Neurology, Chinese Stroke Society. Diagnostic criteria of cerebrovascular diseases in China (version 2019)[J]. Chinese Journal of Neurology, 2019, 52(9): 710-715.] DOI: 10.3760/cma.j.issn.1006?7876. 2019.09.003.

10.蔡业峰, 黄燕, 黄培新, 等. 美国国立卫生院卒中量表（NIHSS）中文版多中心测评研究——附537例缺血中风多中心多时点临床测评研究[J]. 北京中医药大学学报, 2008, 31(7): 494-498. [Cai YF, Huang Y, Huang PX, et al. Study on multi-center investigation of the Chinese version of National Institutes of Health Stroke Scale[J]. Journal of Beijing University of Traditional Chinese Medicine, 2008, 31(7): 494-498.] DOI: 10.3321/j.issn:1006-2157.2008.07.017.

11.Fugl-Meyer AR, Jääskö L, Leyman I, et al. The post-stroke hemiplegic patient. 1. a method for evaluation of physical performance[J]. Scand J Rehabil Med, 1975, 7(1): 13-31. https://pubmed.ncbi.nlm.nih.gov/1135616/.

12.高谦. 中风患者运动功能评价的原则及方法[J]. 中国康复医学杂志, 1993, 8(2): 88-90. [Gao Q. Principles and methods for the evaluation of motor function in stroke patients[J]. Chinese Journal of Rehabilitation Medicine, 1993, 8(2): 88-90.] https://www.doc88.com/p-0049697076485.html.

13.闵瑜, 吴媛媛, 燕铁斌. 改良Barthel指数(简体中文版)量表评定脑卒中患者日常生活活动能力的效度和信度研究[J]. 中华物理医学与康复杂志, 2008, 30(3): 185-188. [Min Y, Wu YY, Yan TB. Validity and reliability of the simplified Chinese version of modified Barthel index for Chinese stroke patients[J]. Chinese Journal of Physical Medicine and Rehabilitation, 2008, 30(3): 185-188.] DOI: 10.3321/j.issn:0254-1424.2008.03.010.

14.沃丽, 杨蓓, 徐梅. 老年急性脑卒中后偏瘫患者康复训练依从性的影响因素[J]. 中华老年多器官疾病杂志, 2024, 23(5): 373-377. [Wo L, Yang B, Xu M. Influencing factors of rehabilitation training compliance in elderly acute stroke patients with hemiplegia[J]. Chinese Journal of Multiple Organ Diseases in the Elderly, 2024, 23(5): 373-377.] DOI: 10.11915/j.issn.1671-5403.2024.05.080.

15.张磊, 高倩, 李欣舒. 基于TLR4/MyD88/NF-κB通路探讨丁苯酞对氧糖剥夺诱导的人脑微血管内皮细胞损伤的影响 [J]. 广东解剖学通报, 2024, 46(4): 330-336. [Zhang L, Gao  Q, Li XS. Investigation of the impact of dibutyl phthalate on oxygen-glucose deprivation-induced human brain micro-vascular endothelial cell injury based on the TLR4/MyD88/NF- κB pathway[J]. Guangdong Anatomy Bulletin, 2024, 46(4): 330-336.] DOI: 10.20021/j.cnki.1671-0770.2024.04.05.

16.姬鹏博, 仵志强, 贾党培, 等. 镜像疗法促进卒中患者上肢运动功能恢复[J]. 国际脑血管病杂志, 2020, 28(3): 180-184. [Ji PB, Wu ZQ, Jia DP, et al. Mirror therapy promotes the recovery of upper extremity motor function in patients with stroke[J]. International Journal of Cerebrovascular Diseases, 2020, 28(3): 180-184.] DOI: 10.3760/cma.j.issn.1673-4165.2020.03.004.

17.Lin LC, Liao CD, Wu CW, et al. Effect of arm sling application on gait and balance in patients with post-stroke hemiplegia: a systematic review and Meta-analysis[J]. Sci Rep, 2021, 11(1): 11161. DOI: 10.1038/s41598-021-90602-y.

18.任玉, 许亮, 任莎莎, 等. 运动想象疗法对脑卒中偏瘫患者上肢功能康复、睡眠障碍及心理状态的影响[J]. 国际精神病学杂志, 2024, 51(5): 1533-1535. [Ren Y, Xu L, Ren SS, et al. The effect of exercise imagination therapy on upper limb function rehabilitation,sleep disorders,and psychological status in patients with hemiplegia after stroke[J]. Journal of International Psychiatry, 2024, 51(5): 1533-1535.] DOI: 10.13479/j.cnki.jip.2024.05.007.

19.隋荣玲, 杨洪兴. 表面肌电生物反馈联合丁苯酞对急性脑梗死偏瘫患者下肢功能恢复的影响[J]. 国际医药卫生导报, 2019, 25(12): 1975-1977. [Sui RL, Yang HX. Effeet of surface electromyography biofeedback combined with butyphthalide on recovery of lowerextremity function in patients with acute cerebral infarction and hemiplegia[J]. International Medicine and Health Guidance News, 2019, 25(12): 1975-1977.] DOI: 10.3760/cma.j.issn.1007-1245.2019.12.036.

20.吴舟娜, 戴方瑜. 康复护理联合丁苯酞治疗中重度急性缺血性脑卒中患者回顾性分析[J]. 药物流行病学杂志, 2014, 23(5): 295-297. [Wu ZN, Dai FY. Retrospective analysis of rehabilitation nursing combined with butylphthalide in the treatment of patients with moderate to severe acute ischemic stroke[J]. Chinese Journal of Pharmacoepidemiology, 2014, 23(5): 295-297.] https://www.cnki.com.cn/Article/CJFDTOTAL-YWLX201405011.htm.