Objective  To explore the application value of the combination of compound α-ketoacid tablet and information-motivation-behavior (IMB) model continuous intervention on patients with stage G2-G3 chronic kidney disease (CKD).

Methods  A total of 100 CKD patients diagnosed and treated in the department of nephrology of Jinhua Hospital of TCM were retrospectively selected from January 2024 to December 2024. According to intervention methods, the enrolled patients were divided into the IMB treatment group (compound α-ketoacid tablet and IMB model continuous intervention) and the conventional treatment group (compound α-ketoacid tablet and conventional intervention). After treatment, the clinical efficacy, renal function indicators [24 h urinary protein quantification, blood urea nitrogen (BUN), serum creatinine (Scr), glomerular filtration rate], metabolic indicators [serum phosphorus, albumin (ALB), prealbumin (PA)], quality of life [kidney disease quality of life-36 (KDQOL-36)], CKD-related complications and adverse drug reactions were observed and compared between groups.

Results  A total of 100 patients with CKD were enrolled in the study, including 46 cases in the IMB treatment group and 54 cases in the conventional treatment group. After treatment, the total clinical effective rate in the IMB treatment group was higher compared to the conventional treatment group (93.48% vs. 79.63%, P<0.05). The 24 h urine protein quantification, BUN, Scr and serum phosphorus in the two groups were reduced compared with those before treatment (P<0.05), and the above indicators were lower in the IMB treatment group than those in the conventional treatment group (P<0.05). The glomerular filtration rate, ALB, PA and KDQOL-36 scores were enhanced in both groups compared to before treatment (P<0.05), and the indicators in the IMB treatment group were higher (P<0.05). No significant differences were exhibited in the incidence rates of CKD-related complications and adverse drug reactions between both groups (P>0.05).

Conclusion IMB model continuous intervention demonstrates significant clinical efficacy in CKD, improving renal function and metabolic status, while also enhancing patient’s quality of life.

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