Agrimoniae herba, derived from the dried aerial parts of Agrimonia pilosa Ledeb., Rosaceae, is a traditional Chinese medicinal herb with abundant resources, and has traditional effects such as convergence, hemostasis, detoxification, and tonifying deficiency. In recent years, research has confirmed that Agrimoniae herba has shown significant potential in the field of anti-tumor treatment, with its main active ingredients including flavonoids, triterpenoids, phenols, coumarins, and tannins. Experimental studies have shown that Agrimoniae herba exerts anti-tumor effects through multi-target synergistic regulation, including inhibition of tumor cell proliferation and angiogenesis, induction of apoptosis, modulation of immune function, and attenuation of oxidative damage. At present, Agrimoniae herba has been widely used in traditional Chinese medicine clinical treatment of various tumors such as colorectal cancer, lung cancer, and gastric cancer. It can not only inhibit tumor growth, delay disease progression, and improve immune function, but also reduce adverse reactions caused by chemotherapy. By systematically reviewing domestic and international literature, this paper comprehensively analyzes the anti-tumor active components, mechanisms of action, and clinical applications of Agrimoniae herba, aiming to provide critical references and scientific foundations for further exploration of its pharmacodynamic material basis and development in anti-tumor therapeutics.

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