Tangerine peel, the dried mature pericarp of Citrus reticulata Blanco and its cultivated varieties, is categorized into two medicinal types, namely “Tangerine Peel” and “Guang Tangerine Peel”. As one of the traditional herbs with both medicinal and edible values in China, it has a long medicinal history and extensive clinical applications. Tangerine Peel is warm in nature, bitter and pungent in taste, and acts on the meridians of the lung and spleen. It is rich in various types of chemical components, such as flavonoids, volatile oils, polysaccharides, and alkaloids. In addition, it exhibits significant pharmacological activities and exerts prominent effects including anti-inflammation, antioxidation, and antitumor activities. Based on relevant domestic and international literature, this paper systematically reviews the chemical components and pharmacological effects of Tangerine Peel, which is expected to provide a scientific basis for further in-depth research on this herb.

1.陈淑娴, 朱佳, 谭喜莹. 陈皮陈用的古今论证与探讨[J]. 上海医药, 2025, 46(4): 87-90. [Chen SX, Zhu J, Tan XY. Discussion on the historical and contemporary theoretical justification of Tangerine Peel[J]. Shanghai Medical & Pharmaceutical Journal, 2025, 46(4): 87-90.] DOI: 10.3969/j.issn.1006-1533.2025.04.019.

2.中国药典2025年版. 一部[S]. 2025: 206-207.

3.Lai CL, Wu H, Ni GJ. Traditional Chinese medicine Pericarpium Citri Reticulatae from Guangdong and Xinhui textual criticism] [J]. Zhongguo Zhong Yao Za Zhi, 2017, 42(4): 789-794. DOI: 10.19540/j.cnki.cjcmm.20170103.010.

4.温宝莹, 陈玉霞, 李嘉俊, 等. 广陈皮黄酮类主成分代谢转化特征研究[J]. 广东化工, 2025, 52(20): 34-37. [Wen BY, Chen YX, Li JJ, et al. Study on the metabolic transformation characteristics of flavonoids from Citrus reticulata 'Chachi'[J]. Guangdong Chemical Industry, 2025, 52(20): 34-37.] DOI: 10.3969/j.issn.1007-1865.2025.020.011.

5.梅全喜, 曾聪彦, 田素英, 等. 陈皮、广陈皮、新会陈皮炮制历史沿革及现代研究进展[J]. 中药材, 2019, 42(12): 2992-2996. [Mei QX, Zeng CY, Tian SY, et al. Historical evolution of processing and modern research progress on Chenpi, Guangchenpi, and Xinhui Chenpi[J]. Journal of Chinese Medicinal Materials, 2019, 42(12): 2992-2996.] DOI: 10.13863/j.issn1001-4454.2019.12.047.

6.Liu Y, Pu H, Li Q, et al. Discrimination of Pericarpium Citri Reticulatae in different years using Terahertz time-domain spectroscopy combined with convolutional neural network[J]. Spectrochim Acta A Mol Biomol Spectrosc, 2023, 286: 122035. DOI: 10.1016/j.saa.2022.122035.

7.支晓娟, 整理. 神农本草经[M]. 广州: 广东科学技术出版社, 2022: 58.

8.尚志钧，辑校. 日华子本草[M]. 合肥：安徽科学技术出版社, 2005: 122.

9.清·汪昂, 编撰. 李可, 点校. 本草备要[M]. 太原: 山西科学技术出版社, 2024: 212.

10.邸莎, 马媛媛, 赵林华. 陈皮的临床应用及其用量探究 [J]. 吉林中医药, 2019, 39(6): 733-736. [Di S, Ma YY, Zhao LH. Clinical application and dosage of dried Tangerine Peel[J]. Jilin Journal of Chinese Medicine, 2019, 39(6): 733-736.] DOI: 10.13463/j.cnki.jlzyy.2019.06.010.

11.李卫霞. 陈皮的药理分析及临床应用研究[J]. 医学理论与实践, 2018, 31(10): 1521-1522, 1555. [Li WX. Pharmacological analysis and clinical application research of Chenpi[J]. The Journal of Medical Theory and Practice, 2018, 31(10): 1521-1522, 1555.] DOI: 10.19381/j.issn.1001-7585.2018.10.068.

12.李伟伟, 张国伟. 陈皮黄酮类成分研究进展[J]. 中国医学创新, 2014, 11(24): 154-156. [Li WW, Zhang GW. Research progress of Tangerine Peel flavonoids[J]. Medical Innovation of China, 2014, 11(24): 154-156.] DOI: 10.3969/j.issn.1674-4985.2014.24.053.

13.童红梅. 陈皮中黄酮类化合物药理作用研究进展[J]. 山西中医学院学报, 2010, 11(3): 75-76. [Tong HM. Research progress on pharmacological effects of flavonoid compounds in Chenpi[J]. Journal of Shanxi University of Chinese Medicine, 2010, 11(3): 75-76.] DOI: 10.3969/j.issn.1671-0258.2010.03.031.

14.王雪, 潘兆平, 陈嘉序, 等. 湖南省16种柑橘陈皮加工适宜性分析[J]. 中国食品学报, 2024, 24(10): 355-370. [Wang  X, Pan ZP, Chen JX, et al. Suitability analysis of 16 citrus varieties for processing Pericarpium Citri Reticulatae in Hunan Province[J]. Journal of Chinese Institute of Food Science and Technology, 2024, 24(10): 355-370.] DOI: 10.16429/j.1009-7848.2024.10.033.

15.文高艳, 周贤梅. 陈皮有效成分在呼吸系统中的作用研究 [J]. 现代中西医结合杂志, 2011, 20(3): 385-386. [Wen GY, Zhou  XM. Study on the effects of active components of Chenpi in the respiratory system[J]. Modern Journal of Integrated Traditional Chinese and Western Medicine, 2011, 20(3): 385-386.] DOI: 10.3969/j.issn.1008-8849.2011.03.087.

16.童红梅. 用HPCL检测不同成药时间陈皮中类黄酮含量及其抗氧化活性[J]. 西部中医药, 2012, 25(7): 17-19. [Tong  HM. Detection of oxidation resisting activity and content of flavonoid in different Chenpi with HPLC[J]. Western Journal of Traditional Chinese Medicine, 2012, 25(7): 17-19.] DOI: 10.3969/j.issn.1004-6852.2012.07.007.

17.王文昌, 徐猛, 赵益菲, 等. 超高效液相色谱法快速测定陈皮及其提取物中4种黄酮类化合物的含量[J]. 理化检验-化学分册, 2022, 58(2): 235-237. [Wang WC, Xu M, Zhao  YF, et al. Rapid determination of the contents of four flavonoids in Chenpi and its extracts by ultra-high performance liquid chromatography[J]. Physical Testing and Chemical Analysis (Part B: Chemical Analysis), 2022, 58(2): 235-237.] DOI: 10.11973/lhjy-hx202202021.

18.曹小敏, 潘思轶. 柑橘属药食同源植物次生代谢物及生物活性研究进展[J]. 食品科学, 2022, 43(23): 305-315. [Cao  XM, Pan SY. Progress in research on secondary metabolites and biological activity of medicinal and edible citrus plants[J]. Food Science, 2022, 43(23): 305-315.] DOI: 10.7506/spkx1002-6630-20220627-302.

19.Sakaki M, Harai K, Takahashi R, et al. Medicine and food with particular reference to Chinpi, dried citrus peel, and a component of Ninjin' yoeito[J]. Neuropeptides, 2021, 89: 102166. DOI: 10.1016/j.npep.2021.102166.

20.徐健, 曾万祥, 王晓东, 等. 陈皮的化学成分与药理学作用研究进展[J]. 中国野生植物资源, 2022, 41(10): 72-76, 106. [Xu J, Zeng WX, Wang XD, et al. Research progress on chemical constituents and pharmacological effects of Tangerine Peel[J]. Chinese Wild Plant Resources, 2022, 41(10): 72-76, 106.] DOI: 10.3969/j.issn.1006-9690.2022.10.013.

21.李俊健, 林锦铭, 高杰贤, 等. 陈皮挥发油提取、成分分析及应用的研究进展[J]. 中国调味品, 2021, 46(8): 169-173. [Li JJ, Lin JM, Gao JX, et al. Research progress on extraction, composition analysis and appl ication of essential oils from Citrus reticulata Blanco[J]. China Condiment, 2021, 46(8): 169-173.] DOI: 10.3969/j.issn.1000-9973.2021.08.036.

22.李思琦, 李华. 陈皮主要化学成分及质量控制研究进展[J]. 今日药学, 2020, 30(12): 861-864. [Li SQ, Li H. Advance of main chemical components and quality control of Citri Reticulatae Pericarpium[J]. Pharmacy Today, 2020, 30(12): 861-864.] DOI: 10.12048/j.issn.1674-229X.2020.12.017.

23.伍锦鸣, 许春平, 王华, 等. 吹扫捕集-气相色谱/质谱/嗅闻法分析陈皮特征头香香气成分[J]. 分析仪器, 2019, (6): 75-78. [Wu JM, Xu CP, Wang H, et al. Analysis of aroma components of Tangerine Peel by PT-GC/MS/O[J]. Analytical Instrumentation, 2019, (6): 75-78.] DOI: 10.3969/j.issn.1001-232x.2019.06.016.

24.王瑞芳, 刘兵, 孙杰, 等. 陈皮的挥发性香气分析[J]. 精细化工, 2022, 39(2): 321-329, 410. [Wang RF, Liu B, Sun J, et al. Volatile aroma analysis of Tangerine Peel[J]. Fine Chemicals, 2022, 39(2): 321-329, 410.] DOI: 10.13550/j.jxhg.20210836.

25.朱丽云, 柳小莉, 郑琴, 等. 陈皮挥发油质量标志物预测及GC-MS定量分析[J]. 中国中药杂志, 2021, 46(24): 6403-6409. [Zhu LY, Liu XL, Zheng Q, et al. Prediction of Q-Markers of Citri Reticulatae Pericarpium volatile oil and GC-MS based quantitative analysis[J]. China Journal of Chinese Materia Medica, 2021, 46(24): 6403-6409.] DOI: 10.19540/j.cnki.cjcmm.20210924.302.

26.李嘉, 张赟赟, 姜平川. 陈皮挥发油的气相色谱指纹图谱研究[J]. 中南药学, 2015, 13(3): 231-233. [Li J, Zhang  YY, Jianng PC. GC fingerprint of volatile oil of orange peel[J]. Central South Pharmacy, 2015, 13(3): 231-233.] DOI: 10.7539/j.issn.1672-2981.2015.03.002.

27.李皓翔, 梅全喜, 赵志敏, 等. 陈皮广陈皮及新会陈皮的化学成分药理作用和综合利用研究概况[J]. 时珍国医国药, 2019, 30(6): 1460-1463. [Li HX, Mei QX, Zhao ZM, et al. Research overview of chemical constituents, pharmacological effects and comprehensive utilization of Chenpi, Guangchenpi and Xinhui Chenpi[J]. Journal of Li-shizhen Traditional Chinese Medicine, 2019, 30(6): 1460-1463.] DOI: 10.3969/j.issn.1008-0805.2019.06.064.

28.李笛帆, 余祥英, 杨金易. 不同陈皮中游离态与键合态挥发性化合物成分分析[J]. 食品安全质量检测学报, 2023, 14(18): 40-49. [Li DF, Yu XY, Yang JY. Composition analysis of free and bound volatile compounds in different Citri Reticulatae Pericarpiums[J]. Journal of Food Safety & Quality, 2023, 14(18): 40-49.] DOI: 10.19812/j.cnki.jfsq11-5956/ts.2023.18.004.

29.何静, 陈谷, 何倩娴, 等. 广陈皮精油的特异性分析[J]. 现代食品科技, 2020, 36(2): 224-231. [He J, Chen G, He QX, et al. Specificity analysis of essential oil from Pericarpium Citri Reticulatae 'Chachiensis'[J]. Modern Food Science and Technology, 2020, 36(2): 224-231.] DOI: 10.13982/j.mfst.1673-9078.2020.2.032.

30.陈树鹏, 刘昊澄, 杨婉媛, 等. 干燥方式对九制陈皮挥发性风味物质的影响[J]. 广东农业科学, 2022, 49(1): 142-150. [Chen  SP, Liu HC, Yang WY, et al. Effect of different drying methods on the volatile flavor of nine-process dried Tangerine Peel[J]. Guangdong Agricultural Sciences, 2022, 49(1): 142-150.] DOI: 10.16768/j.issn.1004-874X.2022.01.017.

31.裴亚萍. 陈皮提取物挥发性香气成分的GC-MS分析[J]. 食品研究与开发, 2017, 38(17): 163-166. [Pei YP. Study on the analysis of volatile aroma components of Pericarpium Citri Reticulate extracts by GC-MS[J]. Food Research and Development, 2017, 38(17): 163-166.] DOI: 10.3969/j.issn.1005-6521.2017.17.036.

32.杜玲玲, 孟晓伟, 胡伊涵, 等. 不同陈化年份陈皮（樟头红）挥发成分差异的电子鼻与HS-GC-MS对比分析[J]. 食品科学, 2025, 46(11): 253-262. [Du LL, Meng XW, Hu YH, et al. Integration of electronic nose and headspace gas chromatography-mass spectrometry for differentiating the volatile compositions of Citri Reticulatae Pericarpium made from Citrus reticulata Blanco var. zhany shuensis f. aged for different years[J]. Food Science, 2025, 46(11): 253-262.] DOI: 10.7506/spkx1002-6630-20241115-117.

33.余祥英, 陈晓纯, 李玉婷, 等. 陈皮挥发油组成分析及其单体的抗氧化性研究[J]. 食品与发酵工业, 2021, 47(9): 245-252. [Yu XY, Chen XC, Li YT, et al. Chemical composition of volatile oil from Citri Retriculatae Pericarpium and its antioxidant activity analysis[J]. Food and Fermentation Industries, 2021, 47(9): 245-252.] DOI: 10.13995/j.cnki.11-1802/ts.025787.

34.黄景晟, 张帅, 刘飞, 等. 超临界CO2萃取陈皮挥发油及其化学成分分析[J]. 现代食品科技, 2013, 29(8): 1961-1966. [Huang JS, Zhang S, Liu F, et al. Extraction of volatile oil from Tangerine Peel by supercritical carbon dioxide (SC-CO2) and analysis of its chemical constituents[J]. Modern Food Science and Technology, 2013, 29(8): 1961-1966.] DOI: 10.13982/j.mfst.1673-9078.2013.08.025.

35.刘发宝, 曾建国, 李文亮, 等. 超临界CO2萃取法和水蒸气蒸馏法提取陈皮挥发油的比较[J]. 中南药学, 2010, 8(12): 883-886. [Liu FB, Zeng JG, Li WL, et al. Constituent of essential oil from tangerine peel by supercritical-CO2 fluid extraction and steam distillation[J]. Central South Pharmacy, 2010, 8(12): 883-886.] DOI: 10.3969/.jissn.1672-2981.2010.12.002.

36.刘丽娜, 傅曼琴, 徐玉娟, 等. 基于GC-MS技术分析不同贮藏年份陈皮挥发性成分差异[J]. 广东农业科学, 2020, 47(9): 114-120. [Liu LN, Fu MQ, Xu YJ, et al. Analysis of differences in volatile components of Pericarpium Citri Reticulatae in different storage years based on GC-MS[J]. Guangdong Agricultural Sciences, 2020, 47(9): 114-120.] DOI: 10.16768/j.issn.1004-874X.2020.09.015.

37.李梦涵, 陈玉婷, 吴继军, 等. 不同温度和湿度对广陈皮色泽及挥发性成分的影响[J]. 南方农业学报, 2024, 55(7): 2006-2020. [Li MH, Chen YT, Wu JJ, et al. Effects of different temperatures and humidities on color and volatile components in Citri reticulata 'Chachi'[J]. Journal of Southern Agriculture, 2024, 55(7): 2006-2020.] DOI: 10.3969/j.issn.2095-1191.2024.07.013.

38.代琪, 罗文凯, 叶俏波, 等. 微生物作用下陈皮陈化前后化学成分及药理作用研究进展[J]. 亚太传统医药, 2024, 20(10): 250-255. [Dai Q, Luo WK, Ye QB, et al. Research progress on changes in chemical composition and pharmacological effects of Tangerine Peel during microbial fermentation[J]. Asia-Pacific Traditional Medicine, 2024, 20(10): 250-255.] DOI: 10.11954/ytctyy.202410056.

39.宋玉鹏, 陈海芳, 谭舒舒, 等. 不同陈皮来源药材中橙皮苷、川陈皮素、橘皮素和辛弗林的含量比较[J]. 时珍国医国药, 2017, 28(9): 2061-2064. [Song YP, Chen HF, Tan SS, et al. A comparative study on content of hesperidin, nobiletin, tangeretin and synephrine in Pericarpium Citri Reticulatae from different varieties[J]. Journal of Li-shizhen Traditional Chinese Medicine, 2017, 28(9): 2061-2064.] DOI: 10.3969/j.issn.1008-0805.2017.09.005.

40.赵祎姗, 黄伟, 王晓宇, 等. 陈皮及青皮药材中辛弗林含量比较研究[J]. 时珍国医国药, 2011, 22(4): 900-901. [Zhao  YS, Huang W, Wang XY, et al. The comparative analysis on the content of synephrine in Pericarpium Citri Reticulate and Pericarpium Citri Reticulatae Viride[J]. Journal of Li-shizhen Traditional Chinese Medicine, 2011, 22(4): 900-901.] DOI: 10.3969/j.issn.1008-0805.2011.04.052.

41.胡媛, 吴蓓, 易达, 等. 基于广泛靶向代谢组学技术与高通量测序技术探究广陈皮陈化机制[J]. 天然产物研究与开发, 2022, 34(4): 553-562. [Hu Y, Wu P, Yi D, et al. Integration of high throughput sequencing and widely targeted metabolomics reveals the aging mechanism of Pericarpium Citri Reticulatae 'Chachiensis'[J]. Natural Product Research and Development, 2022, 34(4): 553-562.] DOI: 10.16333/j.1001-6880.2022.4.002.

42.Yang M, Jiang Z, Wen M, et al. Chemical variation of Chenpi (Citrus Peels) and corresponding correlated bioactive compounds by LC-MS metabolomics and multibioassay analysis[J]. Front Nutr, 2022, 9: 825381. DOI: 10.3389/fnut.2022.825381.

43.Liu N, Li X, Zhao P, et al. A review of chemical constituents and health-promoting effects of Citrus Peels[J]. Food Chem, 2021, 365: 130585. DOI: 10.1016/j.foodchem.2021.130585.

44.张赟赟, 巫凯, 杨海船, 等. 关于陈皮的成分和应用研究进展 [J]. 大众科技, 2023, 25(7): 69-73. [Zhang YY, Wu K, Yang  HC, et al. Research progress on the composition and application of Citri Reticulatae Pericarpium[J]. Popular Science & Technology, 2023, 25(7): 69-73.] DOI: 10.3969/j.issn.1008-1151.2023.07.018.

45.陈韵, 石展望, 黄晓敏. 编程全自动微波密封辅助提取陈皮多糖研究[J]. 时珍国医国药, 2011, 22(1): 140-141. [Chen Y, Shi ZW, Huang XM. Study on programmable automatic microwave-sealed-assisted extraction of polysaccharides from Chenpi[J]. Journal of Li-shizhen Traditional Chinese Medicine, 2011, 22(1): 140-141.] DOI: 10.3969/j.issn.1008-0805.2011.01.068.

46.王福, 李丹, 吴蓓, 等. 广陈皮外观性状与活性成分变化的相关性研究[J]. 时珍国医国药, 2021, 32(3): 761-763. [Wang F, Li D, Wu B, et al. Study on the correlation between the appearance character and the change of active component of the broad-leaved skin[J]. Journal of Li-shizhen Traditional Chinese Medicine, 2021, 32(3): 761-763.] DOI: 10.3969/j.issn.1008-0805.2021.03.73.

47.莫云燕, 黄庆华, 殷光玲, 等. 新会陈皮多糖的体外抗氧化作用及总糖含量测定[J]. 今日药学, 2009, 19(10): 22-25. [Mo  YY, Huang QH, Yin GL, et al. In vitro antioxidative effect and determination of polysaccharides from Xinhui Tangerine Peel[J]. Pharmacy Today, 2009, 19(10): 22-25.] https://www.cnki.com.cn/Article/CJFDTOTAL-YAXU200910020.htm.

48.刘荣, 韦正, 银玲, 等. 星点设计

49.-效应面法优化陈皮多糖提取工艺[J]. 中国实验方剂学杂志, 2013, 19(18): 23-26. [Liu  R, Wei Z, Yin L, et al. Optimization of extraction technology for polysaccharides from Citri Reticulatae Pericarpium by central composite design-response surface methodology[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2013, 19(18): 23-26.] DOI: 10.11653/syfj2013180023.

50.李富荣, 刘雯雯, 文典, 等. 基于矿质元素指纹分析的陈皮产地溯源研究[J]. 食品工业科技, 2022, 43(11): 295-302. [Li FR, Liu WW, Wen D, et al. Study on origin tracing of dried Tangerine Peel using mineral element fingerprints[J]. Science and Technology of Food Industry, 2022, 43(11): 295-302.] DOI: 10.13386/j.issn1002-0306.2021090119.

51.曾育聪, 朱新贵, 陈洪璋, 等. 陈皮柑橘籽中柠檬苦素类物质提取工艺的比较研究[J]. 食品工业科技, 2012, 33(21): 265-268, 272. [Zeng YC, Zhu XG, Chen HZ, et al. Comparative study on extraction technology of limonoids from citrus seeds[J]. Science and Technology of Food Industry, 2012, 33(21): 265-268, 272.] DOI: 10.13386/j.issn1002-0306.2012.21.055.

52.刘雪峰, 杨梅, 向苹苇, 等. 柑橘果皮重要成分及其应用研究进展[J]. 食品与发酵工业, 2024, 50(2): 379-388. [Liu  XF, Yang M, Xiang PW, et al. Research progress on important components of Citrus Peel and their application[J]. Food and Fermentation Industries, 2024, 50(2): 379-388.] DOI: 10.13995/j.cnki.11-1802/ts.033939.

53.杨秀娟, 巢颖欣, 蔡轶, 等. 新会陈皮化学成分的综合分析测定研究[J]. 中国医院药学杂志, 2019, 39(4): 348-352. [Yang XJ, Chao YX, Cai Y, et al. Comprehensive analysis and determination of chemical components in Xinhui Chenpi[J]. Chinese Journal of Hospital Pharmacy, 2019, 39(4): 348-352.] DOI: 10.13286/j.cnki.chinhosppharmacyj.2019.04.07.

54.黄秀芳, 庾国桢, 童晶晶. 基于网络药理学分析陈皮的药理作用机制[J]. 中成药, 2019, 41(12): 3038-3045. [Huang XF, Yu GZ, Tong JJ. Analysis of the pharmacological mechanism of Pericarpium Citri Reticulatae based on network pharmacology[J]. Chinese Traditional Patent Medicine, 2019, 41(12): 3038-3045.] DOI: 10.3969/j.issn.1001-1528.2019.12.043.

55.曹铭希. 陈皮中橙皮苷的提取及其药理活性的研究进展[J]. 中国医药指南, 2012, 10(12): 452-454. [Cao MX. Research progress on extraction and pharmacological activities of hesperidin from Citrus Peel[J]. Guide of China Medicine, 2012, 10(12): 452-454.] DOI: 10.3969/j.issn.1671-8194.2012.12.345.

56.Wang F, Chen L, Chen H, et al. Analysis of flavonoid metabolites in Citrus Peels (Citrus reticulata "Dahongpao") using UPLC-ESI-MS/MS[J]. Molecules, 2019, 24(15). DOI: 10.3390/molecules24152680.

57.唐婷范, 李雪松, 卢梦影, 等. 陈皮多糖提取工艺及其抗氧化活性研究[J]. 中国调味品, 2024, 49(5): 183-187, 204. [Tang TF, Li XS, Lu MY, et al. Study on extraction technology and antioxidant activity of polysaccharides from Tangerine Peel[J]. China Condiment, 2024, 49(5): 183-187, 204.] DOI: 10.3969/j.issn.1000-9973.2024.05.031.

58.崔佳韵, 梁建芬. 不同年份新会陈皮挥发油的抗氧化活性评价[J]. 食品科技, 2019, 44(1): 98-102. [Cui JY, Liang JF. Antioxidant capacities of essential oils in Xinhui Pericarpium Citri Reticulatae at different storage period[J]. Food Science and Technology, 2019, 44(1): 98-102.] DOI: 10.13684/j.cnki.spkj.2019.01.018.

59.张雄飞, 竹剑平. 陈皮提取物对酒精肝的保护作用[J]. 当代医学（学术版）, 2008, (8): 157-158. [Zhang XF, Zhu JP. Protective effect of Pericarpium Citri Reticulatae extract on alcoholic liver disease[J]. Contemporary Medicine, 2008, (8): 157-158.] DOI: 10.3969/j.issn.1009-4393.2008.11.115.

60.Wilmsen PK, Spada DS, Salvador M. Antioxidant activity of the flavonoid hesperidin in chemical and biological systems[J]. J Agric Food Chem, 2005, 53(12): 4757-4761. DOI: 10.1021/jf0502000.

61.Akdemir FNE, Gulcin I, Karagoz B, et al. A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury[J]. J Enzyme Inhib Med Chem, 2016, 31(sup4): 114-118. DOI: 10.1080/14756366.2016.1220378.

62.Tirkey N, Pilkhwal S, Kuhad A, et al. Hesperidin, a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney[J]. BMC Pharmacol, 2005, 5: 2. DOI: 10.1186/1471-2210-5-2.

63.周贤梅, 赵阳, 何翠翠, 等. 陈皮挥发油对大鼠肺纤维化的干预作用（英文）[J]. 中西医结合学报, 2012, 10(2): 200-209. [Zhou XM, Zhao Y, He CC, et al. Preventive effects of Citrus reticulata essential oil on bleomycin-induced pulmonary fibrosis in rats and the mechanism[J]. Journal of Integrative Medicine, 2012, 10(2): 200-209.] DOI: 10.3736/jcim20120211.

64.杨静帆, 李敏艳, 秦燕勤, 等. 川陈皮素的药理活性研究进展[J]. 中医学报, 2023, 38(4): 719-725. [Yang JF, Li MY, Qin YQ, et al. Research progress on pharmacological activity of nobiletin[J]. Acta Chinese Medicine, 2023, 38(4): 719-725.] DOI: 10.16368/j.issn.1674-8999.2023.04.120.

65.Lin N, Sato T, Takayama Y, et al. Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages[J]. Biochem Pharmacol, 2003, 65(12): 2065-2071. DOI: 10.1016/s0006-2952(03)00203-x.

66.陈俊. 川陈皮素对LPS诱导的RAW 264.7细胞损伤的保护作用[J]. 现代食品科技, 2019, 35(10): 44-49. [Chen J. The protective effect of nobiletin on lipopolysaccharides (LPS)-induced RAW 264.7 cell injury[J]. Modern Food Science and Technology, 2019, 35(10): 44-49.] DOI: 10.13982/j.mfst.1673-9078.2019.10.008.

67.Fang ZF, Fu Y, Peng Y, et al. Citrus Peel extract protects against diesel exhaust particle-induced chronic obstructive pulmonary disease-like lung lesions and oxidative stress[J]. Food Funct, 2023, 14(21): 9841-9856. DOI: 10.1039/d3fo02010j.

68.Wang Y, Zhang X, Zhou C, et al. Citri Reticulatae Pericarpium (Chenpi) protects against endothelial dysfunction and vascular inflammation in diabetic rats[J]. Nutrients, 2022, 14(24): 5221. DOI: 10.3390/nu14245221.

69.罗春花, 莫斯锐, 黄杰连, 等. 陈皮的药理作用及产品开发研究进展[J]. 亚太传统医药, 2023, 19(9): 229-234. [Luo CH, Mo SR, Huang JL, et al. Review on pharmacological effect and product development of Pericarpium Citri Reticultae[J]. Asia-Pacific Traditional Medicine, 2023, 19(9): 229-234.] DOI: 10.11954/ytctyy.202309049.

70.Amorim JL, Simas DL, Pinheiro MM, et al. Anti-inflammatory properties and chemical characterization of the essential oils of four citrus species[J]. PLoS One, 2016, 11(4): e0153643. DOI: 10.1371/journal.pone.0153643.

71.许文龙. 免疫系统——人类健康的守护者[J]. 科学生活, 2025, (9): 132-133. [Xu WL. The immune system—the protector of human health[J]. Science & Lifestyle, 2025, (9): 132-133.] DOI: 10.20197/j.cnki.kxsh.2025.09.044.

72.Feng JJ, Maddirala NR, Saint Fleur A, et al. Gut microbiome and immune system crosstalk in chronic inflammatory diseases: a narrative review of mechanisms and therapeutic opportunities[J]. Microorganisms, 2025, 13(11): 2516. DOI: 10.3390/microorganisms13112516.

73.Cappel C, Damme M. The lysosomal catabolism of nucleic acids-critical regulators of the innate immune system[J]. Nucleic Acids Res, 2025, 53(22): gkaf1302. DOI: 10.1093/nar/gkaf1302.

74.丁光, 陈振昆, 李梅, 等. 饲料添加陈皮对草鱼淋巴细胞转化率影响的研究[J]. 云南农业大学学报, 2003, 18(4): 401-403. [Ding G, Chen ZK, Li M, et al. Studies on transformation rate of lymphocyte in grass carp influenced by adding orange peel to base feed[J]. Journal of Yunnan Agricultural University (Natural Science), 2003, 18(4): 401-403.] DOI: 10.16211/j.issn.1004-390x(n).2003.04.020.

75.林巧红, 王芳, 李风琴, 等. 砂仁陈皮制地黄多糖的分离纯化及免疫活性研究[J]. 中国中医基础医学杂志, 2025, 31(10): 1848-1855. [Lin QH, Wang F, Li FQ, et al. Isolation, purification and immunomodulatory activity of polysaccharides from Dihuang processed with Sharen and Chenpi[J]. Journal of Basic Chinese Medicine, 2025, 31(10): 1848-1855.] DOI: 10.19945/j.cnki.issn.1006-3250.2025.10.030.

76.李荣, 李俊, 胡成穆, 等. 橙皮苷对免疫功能低下小鼠免疫调节作用的实验研究[J]. 中国药理学通报, 2007, 23(2): 169-172. [Li R, Li J, Hu CM, et al. Immunomodulative effect of hesperidin on immunodepressed mice[J]. Chinese Pharmacological Bulletin, 2007, 23(2): 169-172.] DOI: 10.3321/j.issn:1001-1978.2007.02.009.

77.Camps-Bossacoma M, Franch A, Perez-Cano FJ, et al. Influence of hesperidin on the systemic and intestinal rat immune response[J]. Nutrients, 2017, 9(6): 580. DOI: 10.3390/nu9060580.

78.金治萃, 胡荫, 白莲花, 等. 桔皮注射液对免疫功能的影响 [J]. 内蒙古医学杂志, 1993, (2): 1-3. [Jin ZC, Hu Y, Bai  LH, et al. Effects of JuPi injection on immune function[J]. Inner Mongolia Medical Journal, 1993, (2): 1-3.] DOI: 10.16096/j.cnki.nmgyxzz.1993.02.001.

79.李茎, 郑鹏, 黎攀, 等. 广陈皮药理作用与临床应用研究进展[J]. 吉林中医药, 2022, 42(9): 1092-1095. [Li J, Zheng  P, Li P, et al. Research progress of pharmacological actions and clinical applications of pericarp of Citrus reticulata 'Chachi'[J]. Jilin Journal of Chinese Medicine, 2022, 42(9): 1092-1095.] DOI: 10.13463/j.cnki.jlzyy.2022.09.025.

80.傅曼琴, 肖更生, 吴继军, 等. 广陈皮促消化功能物质基础的研究[J]. 中国食品学报, 2018, 18(1): 56-64. [Fu MQ, Xiao GS, Wu JJ, et al. Studies on chemical basis of digestion promoting function of Pericarpium Citri Reticulatae (Citrus reticulate 'Chachi')[J]. Journal of Chinese Institute of Food Science and Technology, 2018, 18(1): 56-64.] DOI: 10.16429/j.1009-7848.2018.01.008.

81.虎喜成, 田文荣, 刘敬霞, 等. 加味陈皮膏治疗慢性萎缩性胃炎临床观察[J]. 中国中西医结合消化杂志, 2014, 22(9): 517-520. [Hu XC, Tian WR, Liu JX, et al. Clinical observation on effect of modified Tangerine Peel ointment in treating chronic atrophic gastritis[J]. Chinese Journal of Integrated Traditional and Western Medicine on Digestion, 2014, 22(9): 517-520.] DOI: 10.3969/j.issn.1671-038X.2014.09.08.

82.梅全喜, 林慧, 宋叶, 等. 广陈皮的药理作用与临床研究进展 [J]. 中国医院用药评价与分析, 2019, 19(8): 899-902. [Mei  QX, Lin H, Song Y, et al. Pharmacological actions and clinical research progress of Guangchenpi[J]. Evaluation and Analysis of Drug-Use in Hospitals of China, 2019, 19(8): 899-902.] DOI: 10.14009/j.issn.1672-2124.2019.08.002.

83.舒尊鹏, 胡书法, 翟亚东, 等. 中药枳壳化学成分及药理作用研究[J]. 科技创新与应用, 2012, (17): 8-9. [Shu ZP, Hu  SF, Zhai YD, et al. Research on the chemical components and pharmacological effects of traditional Chinese medicine Fructus Aurantii[J]. Technology Innovation and Application, 2012, (17): 8-9.] DOI: 10.19981/j.cn23-1581/g3.2012.17.008.

84.何占坤, 张国梁, 唐方, 等. 陈皮、藿香不同提取物对胃肠动力障碍大鼠胃肠平滑肌收缩活动及胃肠激素的影响[J]. 天津医药, 2017, 45(11): 1175-1179. [He ZK, Zhang GL, Tang  F, et al. Effects of extracts of Pericarpium Citri Reticulatae and Pogostemon Cablin on the contraction of gastrointestinal smooth muscle and gastrointestinal hormones in rats with gastrointestinal motility disorder[J]. Tianjin Medical Journal, 2017, 45(11): 1175-1179.] DOI: 10.11958/20170739.

85.张旭, 纪忠岐, 赵长敏, 等. 陈皮提取物对小鼠胃排空、肠推进及家兔离体回肠平滑肌的影响[J]. 河南大学学报（医学版）, 2012, 31(1): 12-14. [Zhang X, Ji ZQ, Zhao CM, et al. Effects of Chenpi extract on gastric emptying and small bowel peristalsis in mice in vivo and smooth muscle of ileum of rabbits in vitro[J]. Journal of Henan University(Medical Science), 2012, 31(1): 12-14.] DOI: 10.15991/j.cnki.41-1361/r.2012.01.005.

86.黄敏, 陈有根, 叶小勇, 等. 陈皮贮存期及其功效关系的研究（Ⅱ）不同贮存期陈皮理气作用的药理研究[J]. 中国野生植物资源, 1999, 18(1): 40-42. [Huang M, Chen  YG, Ye XY, et al. Study on the relationship between storage period and efficacy of Chenpi (Ⅱ) pharmacological study on the Qi regulating effect of Chenpi at different storage periods[J]. Chinese Wild Plant Resources, 1999, 18(1): 40-42.] DOI: CNKI:SUN:ZYSZ.0.1999-01-015.

87.王光宁, 史梦娜, 黄月, 等. 广陈皮对功能性消化不良大鼠胃肠动力的影响[J]. 医药导报, 2023, 42(9): 1312-1317. [Wang GN, Shi MN, Huang Y, et al. Effect of Guangchenpi on gastrointestinal motility in functional dyspepsia rats[J]. Herald of Medicine, 2023, 42(9): 1312-1317.] DOI: 10.3870/j.issn.1004-0781.2023.09.008.

88.李庆耀, 梁生林, 褚洪标, 等. 陈皮促胃肠动力有效部位的筛选研究[J]. 中成药, 2012, 34(5): 941-943. [Li QY, Liang SL, Chu HB, et al. Screening of the active fractions of Citri Reticulatae Pericarpium for promoting gastrointestinal motility[J]. Chinese Traditional Patent Medicine, 2012, 34(5): 941-943.] DOI: 10.3969/j.issn.1001-1528.2012.05.045.

89.吕邵娃, 郭红丽, 李影, 等. 六君子汤中理气药陈皮挥发性成分与胃肠动力调节关联性研究[J]. 吉林中医药, 2024, 44(5): 582-589. [Lyu SW, Guo HL, Li Y, et al. Study on the correlation between dried tangerine peel volatile components in Liujunzi decoction and regulation of gastrointestinal motility[J]. Jilin Journal of Chinese Medicine, 2024, 44(5): 582-589.] DOI: 10.13463/j.cnki.jlzyy.2024.05.021.

90.Morford KL, Tetrault JM, O'connor PG. Alcohol and cancer-reply[J]. JAMA, 2025, 335(1): 94. DOI: 10.1001/jama.2025.19212.

91.Fahrmann JF, Irajizad E, Rudsari H, et al. Validation of a blood test for multi-cancer risk stratification in a lung cancer screening cohort[J]. medRxiv, 2025, 2025: 25340518. DOI: 10.1101/2025.11.20.25340518.

92.Pant S, Fan J, Oh DY, et al. Zanidatamab in HER2-positive metastatic biliary tract cancer: final results from HERIZON-BTC-01[J]. JAMA Oncol, 2025, 12(1):106-109. DOI: 10.1001/jamaoncol.2025.4736.

93.韦金红, 韦金双, 吴炜邦, 等. 川陈皮素抗肿瘤机制研究进展[J]. 中国医院药学杂志, 2019, 39(11): 1211-1216. [Wei JH, Wei JS, Wu WB, et al. Research progress in the antitumormechanism effects of Nobiletin[J]. Chinese Journal of Hospital Pharmacy, 2019, 39(11): 1211-1216.] DOI: 10.13286/j.cnki.chinhosppharmacyj.2019.11.22.

94.Song S, Huang W, Lu X, et al. A network pharmacology study based on the mechanism of Citri Reticulatae Pericarpium-Pinelliae Rhizoma in the treatment of gastric cancer[J]. Evid Based Complement Alternat Med, 2021, 2021: 6667560. DOI: 10.1155/2021/6667560.

95.Fernandez-Bedmar Z, Anter J, Alonso-Moraga A, et al. Demethylating and anti-hepatocarcinogenic potential of hesperidin, a natural polyphenol of citrus juices[J]. Mol Carcinog, 2017, 56(6): 1653-1662. DOI: 10.1002/mc.22621.

96.Cincin ZB, Unlu M, Kiran B, et al. Anti-proliferative, apoptotic and signal transduction effects of hesperidin in non-small cell lung cancer cells[J]. Cell Oncol (Dordr), 2015, 38(3): 195-204. DOI: 10.1007/s13402-015-0222-z.

97.辛力, 龚文慧, 郭静英, 等. 天然产物川陈皮素的成分差异及抗肿瘤作用机制研究进展[J]. 中华中医药学刊, 2025, 43(1): 191-195. [Xin L, Gong WH, Guo JY, et al. Research progress on compositional differences and anti-tumor effect mechanism of nobiletin[J]. Chinese Archives of Traditional Chinese Medicine, 2025, 43(1): 191-195.] DOI: 10.13193/j.issn.1673-7717.2025.01.033.

98.钱士辉, 王佾先, 亢寿海, 等. 陈皮提取物体内抗肿瘤作用及其对癌细胞增殖周期的影响[J]. 中国中药杂志, 2003, 28(12): 67-70. [Qian SH, Wang YX, Kang SH, et al. Study on the anticancer activities (in vivo) of the extract from Citrus reticulata Bianco and its influence on sarcoma-180 cells cycle[J]. China Journal of Chinese Materia Medica, 2003, 28(12): 67-70.] DOI: 10.3321/j.issn:1001-5302.2003.12.021.

99.Kim A, Im M, Gu MJ, et al. Citrus unshiu peel extract alleviates cancer-induced weight loss in mice bearing CT-26 adenocarcinoma[J]. Sci Rep, 2016, 6: 24214. DOI: 10.1038/srep24214.

100.Lee J, Kim DH, Kim JH. Combined administration of naringenin and hesperetin with optimal ratio maximizes the anti-cancer effect in human pancreatic cancer via down regulation of FAK and p38 signaling pathway[J]. Phytomedicine, 2019, 58: 152762. DOI: 10.1016/j.phymed.2018.11.022.

101.Park JY, Shin MS, Kim SN, et al. Polysaccharides from Korean Citrus hallabong peels inhibit angiogenesis and breast cancer cell migration[J]. Int J Biol Macromol, 2016, 85: 522-529. DOI: 10.1016/j.ijbiomac.2016.01.015.

102.Kou G, Li Z, Wu C, et al. Citrus tangeretin improves skeletal muscle mitochondrial biogenesis via activating the ampk-pgc1-alpha pathway in vitro and in vivo: a possible mechanism for its beneficial effect on physical performance[J]. J Agric Food Chem, 2018, 66(45): 11917-11925. DOI: 10.1021/acs.jafc.8b04124.

103.Feng K, Zhu X, Liu G, et al. Dietary citrus peel essential oil ameliorates hypercholesterolemia and hepatic steatosis by modulating lipid and cholesterol homeostasis[J]. Food Funct, 2020, 11(8): 7217-7230. DOI: 10.1039/d0fo00810a.

104.史晶晶, 时博. 橙皮苷对高脂血症模型大鼠脂代谢紊乱的影响[J]. 中医学报, 2016, 31(4): 554-557. [Shi JJ, Shi B. Effect of hesperidin on lipid metabolism disorder in hyperlipemia model rats[J]. Acta Chinese Medicine, 2016, 31(4): 554-557.] DOI: 10.16368/j.issn.1674-8999.2016.04.156.

105.李箫纹, 张岭, 曹瑞琪, 等. 橙皮苷对低氧损伤心肌细胞的保护作用[J]. 营养学报, 2025, 47(3): 285-291. [Li XW, Zhang L, Cao RQ, et al. Protective effect of hesperidin on cardiomyocytes injured by hypoXIA[J]. Acta Nutrimenta Sinica, 2025, 47(3): 285-291.] DOI: 10.3969/j.issn.0512-7955.2025.03.013.

106.苏丹, 鲁心安, 秦德安. 陈皮提取液抗衰老作用的实验研究[J]. 上海铁道大学学报（医学辑）, 1999, 20(9): 18-20. [Su D, Lu XA, Qin DA. A Study of antiaging activities of extracts from Pericarpium Citri Reticulatae[J]. Journal of Shanghai Tiedao University (Natural Science Edition), 1999, 20(9): 18-20.] DOI: 10.3969/j.issn.1008-0392.1999.09.007.

107.阚振荣, 于娟. 陈皮提取液的抗菌作用比较[J]. 河北大学学报（自然科学版）, 1998, 18(4): 384-386. [Kan ZR, Yu  J. Antibiotic activity of Pericarpium Citri extract using organic reagents[J]. Journal of Hebei University (Natural Science Edition), 1998, 18(4): 384-386.] DOI: CNKI:SUN:HBDD.0.1998-04-016.

108.张超. 陈皮陈化机制及其生物活性研究进展[J]. 食品科学, 2025-10-24. [Zhang C. Research progress on the aging mechanism and biological activity of Tangerine Peel[J]. Food Science, 2025-10-24.] DOI: 10.7506/spkx1002-6630-20250721-171.