Welcome to visit Zhongnan Medical Journal Press Series journal website!

Home Articles Vol 29,2025 No.12 Detail

Research progress in the treatment of simple obesity with traditional Chinese medicine compounds

Published on Jan. 01, 2026Total Views: 13 times Total Downloads: 2 times Download Mobile

Author: ZHANG Xiali 1, 2 WANG Zhuo 1 MI Li 2

Affiliation: 1. Department of Pharmacy, The First Affiliated Hospital of Naval Medical University, Shanghai 200433, China 2. Department of Pharmacy, Armed Police Force Shanghai General Hospital, Shanghai 201103, China

Keywords: Simple obesity Traditional Chinese medicine compounding Research progress Leptin resistance Insulin resistance Gut microbiota dysbiosis JAK2-STAT3 signaling pathway PI3K/Akt signaling pathway

DOI: 10.12173/j.issn.2097-4922.202510042

Reference: ZHANG Xiali, WANG Zhuo, MI Li. Research progress in the treatment of simple obesity with traditional Chinese medicine compounds[J]. Yaoxue QianYan Zazhi, 2025, 29(12): 2137-2144. DOI: 10.12173/j.issn.2097-4922.202510042.[Article in Chinese]

  • Abstract
  • Full-text
  • References
Abstract

Obesity has become a major global health challenge. Traditional Chinese medicine compounding based on evidence-based treatment for patients with simple obesity has the advantages of good clinical efficacy and high safety. This paper reviews the research progress of traditional Chinese medicine compounding for the treatment of simple obesity from the aspects of the etiology and pathogenesis of simple obesity, identification and typing, clinical treatment and mechanism research.

Full-text
Please download the PDF version to read the full text: download
References

1.中华中医药学会《中医体重管理临床指南》专家组, 广东省针灸学会肥胖专病联盟. 肥胖症中医诊疗方案专家共识[J]. 北京中医药大学学报, 2022, 45(8): 786-794. [Panel of Clinical Guideline for Body Weight Management in TCM of China Association of Chinese Medicine, Obesity League of Guangdong Association of Acupuncture-Moxibustion. Expert consensus on diagnosis and treatment of obesity in TCM[J]. Journal of Beijing University of Traditional Chinese Medicine, 2022, 45(8): 786-794.] DOI: 10.3969/j.issn.1006-2157.2022.08.006.2.

2.中国营养学会肥胖防控分会, 中国营养学会临床营养分会, 中华预防医学会行为健康分会, 等. 中国居民肥胖防治专家共识[J]. 中国预防医学杂志, 2022, 23(5): 321-339. [Chinese Nutrition Society Obesity Prevention and Control Section, Chinese Nutrition Society Clinical Nutrition Section, Chinee Preventive Medicine Association Behavioral Health Section, et al. Expert consensuson obesity prevention and treatment in China[J]. Chinese Preventive Medicine, 2022, 23(5): 321-339.] DOI: 10.16506/j.1009-6639.2022.05.001.

3.Samaranayake NR, Ong KL, Leung RYH, et al. Management of obesity in the National Health and Nutrition Examination Survey (NHANES), 2007-2008[J]. Ann Epidemiol, 2012, 22(5): 349-353. DOI: 10.1016/j.annepidem.2012.01.001.

4.Ng M, Fleming T, Robinson M, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013[J]. Lancet, 2014, 384(9945): 766-781. DOI: 10.1016/S0140-6736(14)60460-8.

5.Swinburn BA, Sacks G, Hall KD, et al. The global obesity pandemic: shaped by global drivers and local environments[J]. Lancet, 2011, 378(9793): 804-814. DOI: 10.1016/S0140-6736(11)60813-1.

6.Wang Y, Xue H, Sun M, et al. Prevention and control of obesity in China[J]. Lancet Glob Health, 2019, 7(9): e1166-e1167. DOI: 10.1016/S2214-109X(19)30276-1.

7.国家卫生健康委员会官网. 体重管理指导原则(2024年版)摘登[J]. 新医学, 2025, 56(6): 627-628. [National Health Commission of the People's Republic of China Official Website. Excerpts from the Weight Management Guidelines (2024 Edition)[J]. New Medicine, 2025, 56(6): 627-628.] DOI: 10.12464/j.issn.0253-9802.2025-0165.

8.陈昱橦, 刘丹璐, 许靖豪, 等. 肥胖症药物治疗的进展、挑战及我国研究现状[J]. 中国普外基础与临床杂志, 2025, 32(9): 1071-1078. [Chen YT, Liu DL, Xu JH, et al. Advances and challenges in pharmacotherapy for obesity in China[J]. Chinese Journal of Bases and Clinics in General Surgery, 2025, 32(9): 1071-1078.] DOI: 10.7507/1007-9424.202506018.

9.刘峰. 除湿降脂方治疗成人单纯性肥胖痰湿内盛证的临床观察[D]. 长沙: 湖南中医药大学, 2022. https://cdmd.cnki.com.cn/Article/CDMD-10541-1022521854.htm.

10.周鑫鑫, 方朝晖. 方朝晖基于疏肝健脾法治疗肥胖的临床经验[J]. 中医药临床杂志, 2022, 34(8): 1435-1438. [Zhou  XX, Fang ZH. Clinical experience of FANG Zhaohui's in treating obesity based on the Shugan Jianpi method[J]. Clinical Journal of Traditional Chinese Medicine, 2022, 34(8): 1435-1438.] DOI: 10.16448/j.cjtcm.2022.0815.

11.王丽君, 彭超宝, 王耀光. 黄文政教授运用越鞠丸治疗肥胖经验浅析[J]. 天津中医药大学学报, 2019, 38(2): 119-121. [Wang LJ, Peng CB, Wang YG. Professor HUANG Wenzheng's use of Yueju pills to treat obesity[J]. Journal of Tianjin University of Traditional Chinese Medicine, 2019, 38(2): 119-121.] DOI: 10.11656/j.issn.1673-9043.2019.02.04.

12.张子浩, 曹舒宇, 关咏昕, 等. 中青年超重/肥胖883例中医证素分布规律[J]. 中医药导报, 2025, 31(9): 112-116. [Zhang  ZH, Cao SY, Guan YX, et al. Distribution patterns of traditional Chinese medicine syndromes among 883 overweight/obese middle-aged and young adults[J]. Guiding Journal of Traditional Chinese Medicine and Pharmacy, 2025, 31(9): 112-116.] DOI: 10.13862/j.cn43-1446/r.2025.09.019.

13.李天鑫, 屈爱卿, 任昕昕, 等. 基于聚类分析8~12岁儿童肥胖症的中医证型分布研究[J]. 世界中西医结合杂志, 2024, 19(11): 2228-2231, 2236. [Li TX, Qu AQ, Ren XX, et al. Distribution of TCM syndrome types of obesity in children aged 8-12 years based on cluster analysis[J]. World Journal of Integrated Traditional and Western Medicine, 2024, 19(11): 2228-2231, 2236.] DOI: 10.13935/j.cnki.sjzx.241121.

14.郭芝东. 146例单纯性肥胖儿童中医证型与饮食因素相关性研究[D]. 成都: 成都中医药大学, 2024. https://cdmd.cnki.com.cn/Article/CDMD-10633-1024664575.htm.

15.滕卉茹, 雷涛, 沙雯君, 等. 单纯性肥胖症不同中医证型的临床特征分析[J]. 浙江中医杂志, 2023, 58(1): 24-26. [Teng HR, Lei T, Sha WJ, et al. Analysis of clinical characteristics of different traditional Chinese medicine syndrome types of simple obesity[J]. Zhejiang Journal of Traditional Chinese Medicine, 2023, 58(1): 24-26.] DOI: 10.3969/j.issn.0411-8421.2023.01.011.

16.涂玉洁, 万红, 王萍, 等. 基于数据挖掘的单纯性肥胖中医证治规律研究[J]. 环球中医药, 2023, 16(7): 1323-1332. [Tu  YJ, Wang H, Wang P, et al. Study on the TCM syndrome and treatment rules of simple obesity based on data mining[J]. Global Traditional Chinese Medicine, 2023, 16(7): 1323-1332.] DOI: 10.3969/j.issn.1674-1749.2023.07.007.

17.金昕, 侯瑞芳, 杨雪蓉, 等. 从多种中医辨证角度探索中医经典古籍对肥胖症病机的认识[J]. 上海中医药杂志, 2023, 57(2): 79-83. [Jin X, Hou RF, Yang XR, et al. Multiple syndrome differentiation-based perspectives to investigate the pathogenesis of obesity in traditional Chinese medicine classics[J]. Shanghai Journal of Traditional Chinese Medicine, 2023, 57(2): 79-83.] DOI: 10.16305/j.1007-1334.2023.2208019.

18.张夏丽, 王卓, 米丽. 中药复方治疗单纯性肥胖的配伍规律与核心方筛选[J]. 解放军药学学报, 2025, 38(01): 31-37. [Zhang XL, Wang Z, Mi L. Compounding pattern and screening of core formulae in the treatment of simple obesity with Chinese medicine compounding[J]. Pharmaceutical Journal of Chinese People's Liberation Army, 2025, 38(1): 31-37.] DOI: 10.3969/j.issn.1008-9926.2025.01.007.

19.黄蔚, 潘丰满, 黄江荣. 加味苓桂术甘汤治疗脾虚湿阻型单纯性肥胖症临床研究[J]. 长江大学学报(自版), 2017, 14(4): 4-6. [Huang W, Pan FM, Huang JR. Clinical research of Reformatted Linggui Zhugan Decoction in the treatment of simple obesity with spleen deficiency dampness obstruction syndrome[J]. Journal of Yangtze University (Natural Science Edition), 2017, 14(4): 4-6.] DOI: 10.16772/j.cnki.1673-1409.2017.04.002.

20.高悦. 佩连麻黄方加味治疗单纯性肥胖伴IGT(胃热滞脾型)的临床观察[D]. 哈尔滨: 黑龙江中医药大学, 2020. https://cdmd.cnki.com.cn/Article/CDMD-10228-1020360478.htm.

21.盛昭园, 胡粤杭, 刘杰, 等. 健脾疏肝降脂方治疗单纯性肥胖的临床疗效及对瘦素脂联素的影响[J]. 世界中医药, 2017, 12(3): 587-590. [Sheng ZY, Hu YH, Liu J, et al. Effect of JianPi ShuGan JiangZhi formula on simple obesity and the expression of leptin and adiponectin[J]. World Chinese Medicine, 2017, 12(3): 587-590.] DOI: 10.3969/j.issn.1673-7202.2017.03.028.

22.邱林杰, 任燕, 李纪新, 等. 温阳化饮方治疗脾肾阳虚型肥胖症患者的临床研究[J]. 中医药学报, 2025, 53(5): 84-90. [Qiu  LJ, Ren Y, Li JX, et al. Clinical study on the treatment of spleen-kidney yang deficiency type obesity with the Wenyang Huayin formula[J]. Acta Chinese Medicine and Pharmacology, 2025, 53(5): 84-90.] DOI: 10.19664/j.cnki.1002-2392.250102.

23.栾振芳, 汪凤茹, 罗斌, 等. 苍附导痰汤加减对痰湿阻滞型单纯性肥胖儿童糖脂代谢的影响[J]. 中国实验方剂学杂志, 2024, 30(3): 90-97. [Luan ZF, Wang FR, Luo B, et al. Effect of Modified Cangfu Daotantang on glucose and lipid metabolism in simple obesechildren with phlegm dampness and stagnation[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2024, 30(3): 90-97.] DOI: 10.13422/j.cnki.syfjx.20230824.

24.史志萍, 刘霄霞, 陆君, 等. 补肾健脾方对围绝经期及绝经期肥胖妇女体质量及性激素水平的影响[J]. 河北中医, 2015, 37(4): 497-500. [Shi ZP, Liu XX, Lu J, et al. Effect of tonifying kidney and spleen herbs on body mass and sex hormone levels in perimenopause and men-opause women with obesity[J]. Hebei Journal of Traditional Chinese Medicine, 2015, 37(4): 497-500.] DOI: 10.3969/j.issn.1002-2619.2015.04.006.

25.黄书晨, 汪一波. 肥胖发病机制的研究进展[J]. 中国分子心脏病学杂志, 2019, 19(5): 3105-3108. [Huang SC, Wang  YB. The progress in the pathogenesis of obesity[J]. Molecular Cardiology of China, 2019, 19(5): 3105-3108.] DOI: 10.16563/j.cnki.1671-6272.2019.10.018.

26.雷耀华, 李欣祝, 刘杉, 等. 中药单体及复方基于瘦素靶点改善肥胖的研究进展[J]. 中医学报, 2025, 40(7): 1371-1376. [Lei YH, Li XZ, Liu S, et al. Research progress on improvement of obesity based on leptin targets in traditional Chinese medicine monomers and relataed compound formula[J]. Acta Chinese Medicine, 2025, 40(7): 1371-1376.] DOI: 10.16368/j.issn.1674-8999.2025.07.220.

27.李璞琳, 胡晓澜, 黄莉吉, 等. 中医药基于炎症反应机制防治肥胖症研究进展[J]. 河北中医, 2025, 47(5): 872-876. [Li PL, Hu XL, Huang LJ, et al. Research advances in the prevention and treatment of obesity based on inflammatory response mechanisms in traditional Chinese medicine[J]. Hebei Journal of Traditional Chinese Medicine, 2025, 47(5): 872-876.] DOI: 10.3969/j.issn.1002-2619.2025.05.037.

28.胡毅龙, 南硕, 黄宝玲, 等. 中药活性成分治疗肥胖症的机制分析[J/OL]. 中国实验方剂学杂志, 2025-10-28. [Hu  YL, Nan S, Huang BL, et al. Analysis of mechanisms of active components of Chinese medicine in treatment of obesity[J/OL]. Chinese Journal of Experimental Traditional Medical Formulae, 2025-10-28.] DOI: 10.13422/j.cnki.syfjx.20252304.

29.皮川, 罗兴, 王鲲鹏, 等. 肥胖、瘦素与肠道微生物菌群的关系及免疫调节作用研究进展[J]. 中国药业, 2025, 34(17): 135-141. [Pi C, Luo X, Wang KP, et al. Research progress on the relationship among obesity, leptin,gut microbiota, and theirimmunomodulatory effects[J]. China Pharmaceuticals, 2025, 34(17): 135-141.] DOI: 10.3969/j.issn.1006-4931.2025.17.028.

30.Farooqi IS, Matarese G, Lord GM, et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency[J]. J Clin Invest, 2002, 110(8): 1093-1103. DOI: 10.1172/JCI15693.

31.朱梦梦. 化积健脾汤对单纯性肥胖小鼠糖脂代谢功能和瘦素抵抗的作用及机制研究[D]. 石家庄: 河北大学, 2020. https://cdmd.cnki.com.cn/Article/CDMD-10075-1020753015.htm.

32.周慧敏. 温肾健脾化痰方调控单纯性肥胖大鼠脂代谢及瘦素抵抗的机制研究[D]. 武汉: 湖北中医药大学, 2017. https://cdmd.cnki.com.cn/Article/CDMD-10507-1017093877.htm.

33.刘曼曼, 冯珍凤, 胡春平, 等. 滋膵降糖方介导Fetuin B-AMPK/ACC通路对高脂诱导肥胖小鼠肝脏胰岛素抵抗的调控机制研究[J]. 西部中医药, 2024, 37(2): 14-19. [Liu MM, Feng ZF, Hu CP, et al. Study on regulatory mechanism of Fetuin B-AMPK/ACC pathway mediated by Zicui Jiangtang prescription on insulin resistance in liver of high-fat-induced obese mice[J]. Western Journal of Traditional Chinese Medicine, 2024, 37(2): 14-19.] DOI: 10.12174/j.issn.2096-9600.2024.02.04.

34.姚庆, 王浩安, 高文婷, 等. 脂肪细胞分泌的炎症因子及相关信号通路介导的肥胖和胰岛素抵抗[J]. 大连医科大学学报, 2022, 44(4): 341-345. [Yao Q, Wang HA, Gao WT, et al. Implication of inflammatory cytokines secreted by adipocytes and associated signaling pathways in obesity and insulin resistance[J]. Journal of Dalian Medical University, 2022, 44(4): 341-345.] DOI: 10.11724/jdmu.2022.04.10.

35.喻松仁, 刘彩玲, 周丽, 等. 温胆汤通过调控PI3K/Akt/mTOR通路介导的脂肪细胞自噬对肥胖痰湿证炎症状态的影响[J]. 中国实验方剂学杂志, 2023, 29(14): 1-10. [Yu SR, Liu  CL, Zhou L, et al. Effect of Wendan Tang on inflammatory state of obesity phlegm-dampness syndrome through regulating PI3K/Akt/mTOR pathway-mediated adipocyte autophagy[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2023, 29(14): 1-10.] DOI: 10.13422/j.cnki.syfjx.20230540.

36.陈璐佳, 刘宏飞, 邓艳华, 等. 消脂合剂调节PI3K/Akt/mTOR信号通路对肥胖小鼠糖脂代谢的影响[J]. 中国现代医生, 2024, 62(7): 67-72, 84. [Chen LJ, Liu HF, Deng YH, et al. Xiaozhi mixture regulates PI3K/Akt/mTOR signaling pathway on glucose and lipid metabolism in obese mice[J]. China Modern Doctor, 2024, 62(7): 67-72, 84.] DOI: 10.3969/j.issn.1673-9701.2024.07.017.

37.颜青. 防己黄芪汤对小鼠3T3-L1前脂肪细胞分化及炎症因子基因表达的影响[D]. 银川: 宁夏医科大学, 2018. https://cdmd.cnki.com.cn/Article/CDMD-10752-1017839253.htm.

38.孙怡婕, 冯强, 张栩, 等. 消脂方调控NF-κB炎症信号通路对高脂饮食诱导肥胖小鼠糖代谢及胰岛素抵抗的影响[J]. 现代中西医结合杂志, 2021, 30(2): 125-132. [Sun  YJ, Feng Q, Zhang Y, et al. Effect of regulation of NF-κB inflammatory signaling pathway by Xiaozhi Decoction on glucose metabolism and insulin resistance in mice with diet-induced obesity[J]. Modern Journal of Integrated Traditional Chinese and Western Medicine, 2021, 30(2): 125-132.] DOI: 10.3969/j.issn.1008-8849.2021.02.003.

39.张景惠. 基于PPARγ/RXRα探究化积健脾汤对单纯性肥胖的治疗作用及其作用机制研究[D]. 石家庄: 河北大学, 2023. https://cdmd.cnki.com.cn/Article/CDMD-10075-1023428354.htm.

40.宁莹. 苓桂术甘汤调控肠道菌群结构及代谢改善胰岛素抵抗的机制探究[D]. 成都: 成都中医药大学, 2022. https://cdmd.cnki.com.cn/Article/CDMD-10633-1023841834.htm.

41.艾梓黎, 张娴, 葛巍, 等. 四物汤水提物对肥胖大鼠肠道菌群平衡的调控作用[J]. 中华中医药学刊, 2023, 41(7): 136-140. [Ai ZL, Zhang X, Ge W, et al. Effects of Siwu decoction water extract via miltiorrhiza on intestinal microflora balance in obese rats induced by high-fat diet[J]. Chinese Archives of Traditional Chinese Medicine, 2023, 41(7): 136-140.] DOI: 10.13193/j.issn.1673-7717.2023.07.08.

42.李若楠, 王萍, 王晨晓, 等. 清胃泄热方对肥胖大鼠肠道菌群的影响[J]. 世界中医药, 2025, 20(15): 2662-2670. [Li RN, Wang  P, Wang CX, et al. Effect of Qingwei Xiere formula on intestinal flora of obese rats[J]. World Chinese Medicine, 2025, 20(15): 2662-2670.] DOI: 10.3969/j.issn.1673-7202.2025.15.010.

Popular papers
Last 6 months