Optimization of the matrix formulation of Shangjin Zhitong gel patch by Box-Behnken response surface methodology

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Author: LONG Zechun ¹ LIU Yang ² SHI Qiongzhi ³  LIU Hui ^1, ³  XIONG Chengjie ⁴ HU Hua ³

Affiliation: 1. School of Pharmaceutical Sciences, Hubei University of Medicine, Shiyan 442000, Hubei Province, China 2. School of Medicine, Wuhan University of Science and Technology, Wuhan 430065, China 3. Medical Support Center, General Hospital of Central Theater Command of PLA, Wuhan 430070, China 4. Department of Orthopedic Surgery, General Hospital of Central Theater Command of PLA, Wuhan 430070, China

Keywords: Shangjin Zhitong gel Gel patch Formulation optimization Box-Behnken response surface methodology

DOI: 10.12173/j.issn.2097-4922.202412047

Reference: LONG Zechun, LIU Yang, SHI Qiangzhi, LIU Hui, XIONG Chengjie, HU Hua. Optimization of the matrix formulation of Shangjin Zhitong gel patch by Box-Behnken response surface methodology[J]. Yaoxue QianYan Zazhi, 2025, 29(5): 747-755. DOI: 10.12173/j.issn.2097-4922.202412047.[Article in Chinese]  Copied

Abstract
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Abstract

Objective To optimize and validate the formualtion and preparation process of Shangjin Zhitong gel patch.

Methods The dosage of glycerol, sodium polyacrylate NP700, citric acid, and aluminum glycinate were used as influencing factors, and the sensory score and the total score of initial adhesion were used as evaluation indicators. The Box-Behnken response surface methodology was used to optimize the matrix formula of the gel patch.

Results The optimal matrix formula was 17.30 g of glycerol, 2.40 g of sodium polyacrylate NP700, 0.1 g of aluminum glycinate, and 0.1 g of citric acid, with a total score of 87.502 points.

Conclusion The matrix formula of the gel patch is stable and reliable, and the obtained gel patch is of good quality.

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