This paper systematically reviews the current status of resource distribution, standard inclusion, and quality control research on medicinal materials from the folk medicine Callerya. Although the plant resources of this genus are abundant in China, only a few species have been included in provincial medicinal material standards, reflecting an unbalanced utilization and standardization of these resources. Studies have confirmed that flavonoids serve as the core pharmacodynamic material basis. Currently, modern techniques such as DNA molecular identification, chromatography-mass spectrometry analysis, fingerprint analysis, and content determination have been widely applied in quality control research on medicinal materials from this genus, laying a solid foundation. However, the current quality control system still faces significant limitations, including a "fragmented" quality standard system, "simplified" quality control indicators, and a "delayed" transformation of advanced technologies. To address these challenges and promote the high-quality development of medicinal materials from this genus, this paper proposes an integrated quality control system that combines "DNA-based accurate identification + characteristic chromatogram-based holistic control + multi-component content determination". This system aims to facilitate the transition from "folk experience" to "modern medicine", providing a theoretical basis for resource conservation, quality evaluation, and in-depth development of medicinal plants in the Callerya.

1. 徐国钧, 徐珞珊, 主编. 常用中药材品种整理和质量研究. 南方协作组, 第二册 [M]. 福州: 福建科学技术出版社, 1997: 521-574.

2. ZhiWP, LuDZ. Flora of China, Volume 10[M]. Beijing: Science Press, 2010: 176-187.

3. 熊瑶, 金晨, 曹岚, 等. 我国崖豆藤属药用植物研究进展[J]. 中药材, 2020, 43(4): 1012-1019.XiongY, JinC, CaoL, et al. Research progress on medicinal plants of Millettia in China[J]. Journal of Chinese Medicinal Materials, 2020, 43(4): 1012-1019. DOI: 10.13863/j.issn1001-4454.2020.04.044.

4. 张庆熙, 金晨, 陈康, 等. 我国鸡血藤属和崖豆藤属药用植物的研究现状及比较[J]. 中国实验方剂学杂志, 2021, 27(16): 198-208.ZhangQX, JinC, ChenK, et al. Research status and comparison of medicinal plants of Spatholobus and Millettia in China[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2021, 27(16): 198-208. DOI: 10.13422/j.cnki.syfjx.20210856.

5. LiaoXL, LuoJG, KongLY. Flavonoids from Millettia nitida var. hirsutissima with their anticoagulative activities and inhibitory effects on NO production[J]. J Nat Med, 2013, 67(4): 856-861. DOI: 10.1007/s11418-013-0764-3.

6. YeH, WuW, LiuZ, et al. Bioactivity-guided isolation of anti-inflammation flavonoids from the stems of Millettia dielsiana Harms[J]. Fitoterapia, 2014, 95: 154-159. DOI: 10.1016/j.fitote.2014.03.010.

7. GongT, WangDX, ChenRY, et al. Novel benzil and isoflavone derivatives from Millettia dielsiana[J]. Planta Med, 2009, 75(3): 236-242. DOI: 10.1055/s-0028-1112203.

8. 张凌, 刘亚丽, 饶志军, 等. 丰城鸡血藤对小鼠造血系统损伤保护作用[J]. 中国现代应用药学, 2009, 26(5): 349-353.ZhangL, LiuYL, RaoZJ, et al. Protective effect of Millettia nitida var. hirsutissima on hematopoietic system injury in mice[J]. Chinese Journal of Modern Applied Pharmacy, 2009, 26(5): 349-353. DOI: 10.13748/j.cnki.issn1007-7693.2009.05.002.

9. 杨其波, 陆炜高, 屈庆群, 等. 牛大力对亚健康小鼠血常规影响的实验研究[J]. 河南中医, 2016, 36(7): 1147-1149.YangQB, LuWG, QuQQ, et al. Experimental research of the influence of Nidali (Radix Millettiae Speciosae) on sub-health mice's blood routine examination[J]. Henan Traditional Chinese Medicine, 2016, 36(7): 1147-1149. DOI: 10.16367/j.issn.1003-5028.2016.07.0475.

10. 李才堂, 王小青, 康明, 等. 丰城鸡血藤总黄酮抗血小板聚集及抗血栓作用研究[J]. 中国现代应用药学, 2015, 32(11): 1316-1318.LiCT, WangXQ, KangM, et al. Studies on antiplatelet aggregation and antithrombosis action of total flavonoids of Millettia Nitida var. Hirsutissima Z. Wei[J]. Chinese Journal of Modern Applied Pharmacy, 2015, 32(11): 1316-1318. DOI: 10.13748/j.cnki.issn 1007-7693.2015.11.008.

11. HsuCC, HsuCL, TsaiSE, et al. Protective effect of Millettia reticulata Benth against CCl₄-induced hepatic damage and inflammatory action in rats[J]. J Med Food, 2009, 12(4): 821-828. DOI: 10.1089/jmf.2008.1206.

12. ChenX, SunW, XuB, et al. Polysaccharides from the roots of Millettia Speciosa Champ modulate gut health and ameliorate cyclophosphamide-induced intestinal injury and immunosuppression[J]. Front Immunol, 2021, 12: 766296. DOI: 10.3389/fimmu.2021.766296.

13. 贾敏如, 张艺, 主编. 中国民族药辞典[M]. 北京: 中国医药科技出版社, 2016: 534-535.

14. 国家中医药管理局《中华本草》编委会, 编著. 中华本草(第四册)[M]. 上海: 上海科学技术出版社, 1999: 563-573.

15. 南京中医药大学, 编著. 中药大辞典(上册), 第2版[M]. 上海: 上海科学技术出版社, 2006: 422, 573, 1232, 1890.

16. 萧步丹, 主编. 岭南采药录[M]. 广州: 广东科技出版社, 2009: 112-113.

17. 原广州部队后勤部卫生部, 编著. 常用中草药手册[M]. 北京: 人民卫生出版社, 1969: 89-90.

18. 原江西省卫生局革命委员会, 编著. 江西草药[M]. 南昌: 江西省新华书店, 1970: 32-33.

19. 清·吴其浚, 著.植物名实图考[M]. 上海: 商务印书馆, 1857: 573.

20. 原湖北省革命委员会卫生局, 编著. 湖北中草药志(第一册)[M]. 武汉: 湖北人民出版社, 1978: 80-81.

21. 广西壮族自治区中医药研究所, 编著. 广西药用植物名录[M]. 南宁: 广西人民出版社, 1986: 109-110.

22. 云南省药物研究所. 云南药用植物名录[R]. 1975: 58-60.

23. 原广西壮族自治区革命委员会卫生局, 编著. 广西本草选编[M]. 南宁:广西人民出版社, 1974: 102-103.

24. 云南省药材公司, 编著. 云南中药资源名录[M]. 北京: 科学出版社, 1993: 78-79.

25. 云南省卫生局, 编著. 云南中草药选[M]. 昆明: 云南人民出版社, 1971: 90-92.

26. 湖南省商业厅, 编著. 湖南野生植物[M]. 长沙: 湖南省科学技术普及协会, 1958: 76-78.

27. 蔡光先, 主编. 湖南药物志[M]. 长沙: 湖南科学技术出版社, 2004: 345-346.

28. 原浙江省革命委员会生产指挥组卫生办公室, 编著. 浙江民间常用草药(第一辑)[M]. 杭州: 浙江人民出版社, 1969: 56-58.

29. 原广西壮族自治区革命委员会卫生管理服务站, 编著. 广西中草药[M]. 南宁: 广西人民出版社, 1970: 67-68.

30. 原广东省食品药品监督管理局. 广东省中药材标准(第一册)[S]. 广州: 广东科技出版社, 2004: 40.

31. 原山西省食品药品监督管理局. 山西省中药材中药饮片标准(第一册)[S]. 北京: 科学技术出版社, 1997: 10.

32. 北京市药品监督管理局. 北京市中药饮片炮制规范 (2008年版)[S]. 北京: 化学工业出版社, 2008: 23.

33. 原广西壮族自治区食品药品监督管理局. 广西壮族自治区壮药质量标准(第一卷, 2008年版)[S]. 南宁: 广西科学技术出版社, 2008: 61.

34. 原福建省食品药品监督管理局. 福建省中药饮片炮制规范 (2012年版)[S]. 福州: 福建科学技术出版社, 2012: 45-46.

35. 原河北省食品药品监督管理局. 河北省中药饮片炮制规范 (2003年版)[S]. 北京: 学苑出版社, 2003: 26.

36. 原湖南省食品药品监督管理局,. 湖南省中药饮片炮制规范 (2010年版)[S]. 长沙: 湖南科学技术出版社, 2010: 139-140.

37. 原江西省食品药品监督管理局. 江西省中药饮片炮制规范 (2008年版)[S]. 上海: 上海科学技术出版社, 2008: 174.

38. 湖北省药品监督管理局. 湖北省中药材质量标准 (2018年版)[S]. 北京: 中国医药科技出版社, 2018: 136-137.

39. 原四川省食品药品监督管理局. 四川省中药材标准 (2010年版)[S]. 成都: 四川科学技术出版社, 2010: 54-58.

40. 戴蒙, 潘超美, 彭泽通, 等. 牛大力两种根的生药学研究[J]. 时珍国医国药, 2021, 32(1): 100-102.DaiM, PanCM, PengZT, et al. Pharmacognostic study on two kinds of roots of Millettia speciosa Champ[J]. Lishizhen Medicine and Materia Medica Research, 2021, 32(1): 100-102. DOI: 10.3969/j.issn.1008-0805.2021.01.27.

41. 陈黄保. 甜牛大力和苦牛大力的生药研究[J]. 中草药, 2001, 32(9): 843-845.ChenHB. Pharmacognostic studies on Tianniudali (Radix Millettia speciosa) and Kuniudali (Radix Millettia championi)[J]. Chinese Traditional and Herbal Drugs, 2001,32(9): 843-845. DOI: 10.3321/j.issn:0253-2670.2001.09.040.

42. 曾瞻. 丰城鸡血藤与香花崖豆藤的鉴定区别[J]. 井冈山医专学报, 2005, 12(1): 79-80. [ZengZ. Identification of millettia nitida and millettia dielsiana[J]. Journal of Jinggangshan Medical College, 2005, 12(1): 79-80.https://d.wanfangdata.com.cn/periodical/jgsyzxb200501058.

43. 王丽静, 肖草茂, 曾宪仪. 丰城鸡血藤的生药学鉴定[J]. 华西药学杂志, 2015, 30(4): 452-453.WangLJ, XiaoCM, ZengXY. Pharmacognostical identification of Millettia nitida[J]. West China Journal of Pharmaceutical Sciences, 2015, 30(4): 452-453. DOI: 10.13375/j.cnki.wcjps.2015.04.022.

44. 罗露香, 罗景斌, 刘基柱, 等. 山鸡血藤的生药学鉴别[J]. 中药材, 2020, 43(7): 1567-1571.LuoLX, LuoJB, LiuJZ, et al. Pharmacognostic Identification of Millettia dielsiana[J]. Journal of Chinese Medicinal Materials, 2020, 43(7): 1567-1571. DOI: 10.13863/j.issn1001-4454.2020.07.009.

45. 翟明. 鸡血藤种质资源的鉴定与品质评价[D]. 广州: 广州中医药大学, 2010. https://d.wanfangdata.com.cn/thesis/Ch1UaGVzaXNOZ XdTb2xyOVMyMDI2MDUxMjA3Mjk0NxIJRDAxMzIwMTkwGghwNmRza2xyYg%3D%3D.

46. 安冉, 杨锦芬, 刘军民, 等. 基于26S rDNA D1-D3区序列分析的鸡血藤及其混淆品的分子鉴别[J]. 广州中医药大学学报, 2010, 27(4): 403-406. [AnR, YangJF, LiuJM, et al. Molecular identification of Spatholobi caulis and its adulterants based on sequence analysis of 26S rDNA D1-D3 region[J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2010, 27(4): 403-406.04020.https://d.wanfangdata.com.cn/periodical/gzzyydxxb2010

47. 熊瑶, 金晨, 王晓云, 等. 鸡血藤及其混伪品的DNA条形码分子鉴定研究[J]. 中草药, 2020, 51(12): 3274-3283.XiongY, JinC, WangXY, et al. Molecular identification of Spatholobi Caulis and its adulterants based on DNA barcoding[J]. Chinese Traditional and Herbal Drugs, 2020, 51(12): 3274-3283. DOI: 10.7501/j.issn.0253-2670.2020.12.020.

48. 李丽, 李志英, 黄碧兰, 等. 美丽鸡血藤种质资源遗传多样性的ISSR分析[J]. 热带作物学报, 2013, 34(12): 2320-2325.LiL, LiZY, HuangBL, et al. ISSR analyasis of genetic diversity in Callerya speciosa accessions[J]. Chinese Journal of Tropical Crops,  2013,  34(12):  2320-2325.  DOI:  10.3969/j.issn.1000-2561.2013.12.003.

49. 翟明, 刘军民, 安冉, 等. 鸡血藤类药材种质资源的RAPD分析[J]. 中药新药与临床药理, 2010, 21(4): 413-415.ZhaiM, LiuJM, AnR, et al. RAPD analysis on germplasm resources of Spatholobi caulis[J]. Traditional Chinese Drug Research and Clinical Pharmacology, 2010, 21(4): 413-415. DOI: 10.19378/j.issn.1003-9783.2010.04.025.

50. ChenZ, JinC, WangXY, et al. Characterization of the complete chloroplast genome of four species in Callerya[J]. J AOAC Int, 2023, 106(1): 146-155. DOI: 10.1093/jaoacint/qsac096.

51. YiQF, HanLN, LinMC, et al. The complete chloroplast genome of ornamental and medicinal Callerya dielsiana (Fabaceae)[J]. Mitochondrial DNA B Resour, 2022, 7(8): 1416-1417. DOI: 10.1080/23802359.2022.2104671.

52. YuD D, LiangX R. Characterization and identification of isoflavonoids in the roots of Millettia speciosa Champ. by UPLC-Q-TOF-MS/ MS[J]. Curr Pharm Anal, 2019, 15(6): 580-591. https://www.eurekaselect.com/article/91001. doi：10.2174/1573412914666180608095922

53. 陈德力, 弓宝, 刘洋洋, 等. 牛大力根脂溶性成分的GC-MS分析[J]. 陕西中医, 2015, 36(9): 1248-1250.ChenDL, GongB, LiuYY, et al. GC-MS analysis of fat-soluble constituents from the roots of Millettia speciosa[J]. Shaanxi Journal of Traditional Chinese Medicine, 2015, 36(9): 1248-1250. DOI: 10.3969/j.issn.1000-7369.2015.09.076.

54. YeM, YangWZ, LiuKD, et al. Characterization of flavonoids in Millettia nitida var. hirsutissima by HPLC/DAD/ESI-MSn[J]. J Pharm Anal, 2012, 2(1): 35-42. DOI: 10.1016/j.jpha.2011.09.006.

55. 赵艳红. 丰城鸡血藤抗RA药效物质基础及活性研究[D]. 南昌: 江西中医药大学, 2019. https://cdmd.cnki.com.cn/Article/CDMD-10412-1019695066.htm.

56. 刘亚丽, 魏韶锋, 宋永贵, 等. UPLC/Q-TOF-MS/MS法分析丰城鸡血藤中刺芒柄花素在大鼠肠道菌群中的代谢[J]. 中国新药杂志, 2015, 24(23): 2715-2723. [LiuYL, WeiSF, SongYG, et al. Metabolism of formononetin in Millettia nitida Benth. var. hirsutissima Z. Wei extract co-incubated with rat intestinal flora by UPLC/Q-TOF-MS/MS[J]. Chinese Journal of New Drugs, 2015, 24(23): 2715-2723.https://d.wanfangdata.com.cn/periodical/zgxyzz201523015.

57. 张剑光, 陈明, 施雪敏, 等. 牛大力HPLC指纹图谱及化学模式识别研究[J]. 中药材, 2019, 42(10): 2343-2346.ZhangJG, ChenM, ShiXM, et al. HPLC fingerprint and chemical pattern recognition of Millettia speciosa[J]. Journal of Chinese Medicinal Materials, 2019, 42(10): 2343-2346. DOI: 10.13863/j.issn1001-4454.2019.10.027.

58. 张凌, 刘亚丽, 饶志军. 丰城鸡血藤活性成分HPLC指纹图谱研究[J]. 江西中医学院学报, 2008, 20(1): 80-84.ZhangL, LiuYL, RaoZJ. HPLC fingerprint spectrum of Millettia nitida Benth var hirsutissima Z Wei[J]. Journal of Jiangxi University of Traditional Chinese Medicine, 2008, 20(1): 80-84. DOI: 10.3969/j.issn.1005-9431.2008.01.032.

59. 陈明权, 彭富全, 何风雷, 等. HPLC同时测定牛大力中刺桐碱和高丽槐素的含量[J]. 中国现代中药, 2018, 20(1): 39-41, 53.ChenMQ, PengFQ, HeFL, et al. Simultaneous determination of erythraline and maackiain in Millettia speciosa by HPLC[J]. Modern Chinese Medicine, 2018, 20(1): 39-41, 53. DOI: 10.13313/j.issn.1673-4890.20170717002.

60. 彭富全, 陈明权, 林励, 等. HPLC测定不同品种牛大力中刺桐碱、芒柄花素和高丽槐素的含量[J]. 广州中医药大学学报, 2018, 35(3): 507-511.PengFQ, ChenMQ, LinL, et al. Determination of contents of hypaphorine, formononetin and maackiain in different varieties of Millettia speciosa Champ. by HPLC[J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2018, 35(3): 507-511. DOI: 10.13359/j.cnki.gzxbtcm.2018.03.027.

61. 李荣宇, 林少玲, 骆月姬, 等. 不同产地牛大力水提物中总黄酮、总皂苷及总多糖的含量测定[J]. 中国药师, 2020, 23(6): 1208-1210. [LiRY, LinSL, LuoYJ, et al. Content determination of total flavonoids, saponins and polysaccharides in Millettia speciosa Champ. from different producing areas[J]. China Pharmacist, 2020, 23(6): 1208-1210.202006047.https://d.wanfangdata.com.cn/periodical/zgys

62. 杜顺霞, 蒙雪芳, 王柳萍, 等. HPLC测定苦牛大力根部和甜牛大力不同部位中芒柄花素和高丽槐素的含量[J]. 广西医科大学学报, 2017, 34(8): 1237-1240.DuSX, MengXF, WangLP, et al. Quantification of maackiain and formononetinin root of Radix Millettia Championi and different parts of Radix Millettia Speciosa by HPLC[J]. Journal of Guangxi Medical University, 2017, 34(8): 1237-1240. DOI: 10.16190/j.cnki.45-1211/r.2017.08.036.

63. 马留辉, 庞婷, 何欢, 等. 基于ICP-MS法测定牛大力重金属污染水平的研究[J]. 广西农学报, 2020, 35(2): 46-49.MaLH, PangT, HeH, et al. Determination of heavy metals in radix millettiae speciosa by ICP-MS method[J]. Journal of Guangxi Agriculture, 2020, 35(2): 46-49. DOI: 10.3969/j.issn.1003-4374. 2020.02.011.

64. 龙洲雄, 万春花, 余燕影, 等. 高效液相色谱法测定丰城鸡血藤中四种黄酮类化合物[J]. 分析测试学报, 2006, 25(6): 104-107.LongZX, WanCH, YuYY, et al. Determination of flavones in Millettia dielsiana Harms extract by high performance liquid chromatography[J]. Journal of Instrumental Analysis, 2006, 25(6): 104-107. DOI: 10.3969/j.issn.1004-4957.2006.06.029.

65. 余燕影, 章丽华, 曹树稳. RP-HPLC法测定丰城鸡血藤提取物中大豆黄酮、染料木素、刺芒柄花素和美皂异黄酮[J]. 中草药, 2006, 37(11): 1655-1656.YuYY, ZhangLH, CaoSW. Determination of daidzein, genistein, formononetin, and biochanin A in Millettla nitida var. hirsutissima extract by RP-HPLC[J]. Chinese Traditional and Herbal Drugs, 2006, 37(11): 1655-1656. DOI: 10.3321/j.issn:0253-2670.2006.11.021.

66. 余燕影, 彭志兵, 曹树稳. 紫外分光光度法测定丰城鸡血藤中总黄酮[J]. 中草药, 2005, 36(11): 1650-1651.YuYY, PengZB, CaoSW. Determination of total flavonoids in Millettia nitida var. hirsutissima by UV spectrophotometry[J]. Chinese Traditional and Herbal Drugs, 2005, 36(11): 1650-1651. DOI: 10.3321/j.issn:0253-2670.2005.11.022.

67. XiangC, LiangH, WangB, et al. Reverse-phase high-performance liquid-chromotographic DAD method for simultaneous determination of five isoflavones in Millettia nitida var. hirsutissima[J]. Anal Lett, 2009, 42(8): 1148-1156. DOI: 10.1080/00032710902890413.

68. 何可群, 李相兴. 香花崖豆藤总三萜酸的含量测定[J]. 时珍国医国药, 2014, 25(5): 1070-1071.HeKQ, LiXX. Determination of total triterpene acid from Millettia dielsiana[J].Journal of Li-shizhen Traditional Chinese Medicine, 2014, 25(5): 1070-1071. DOI: 10.3969/j.issn.1008-0805.2014.05.019.