Objective  To explore the research hotspots and development trends of Ziziphi Spinosae Semen in the past 20 years, and to provide reference for related research.

Methods  Literatures on Ziziphi Spinosae Semen were searched from January 1, 2000 to December 31, 2022 in CNKI, Web of Science Core Collection Database. VOS viewer software was used to visually analyze the citation frequency, research institutions and keyword hotspots of English literatures. CiteSpace software was used to visually analyze research institutions, authors, emergence keywords and keyword overlap time of Chinese literatures, and Microsoft Excel 2021 software was used to analyze of annual publication trends and publication volume of Chinese and English literatures, and download frequency of Chinese literatures.

Results  A total of 4 872 Chinese and 128 English literatures were included, with an overall upward trend in the number of annual publications. The research institutions with the highest number of publications in Chinese and English were Shandong University of Traditional Chinese Medicine and Tianjin University of Commerce, and the authors with the highest number of publications were DU Chenhui and XIE Junbo, respectively. The most frequent keywords in Chinese literatures were "Ziziphi Spinosae Semen”, “composed” and “application of compound therapy”, and in English literatures were "performance", "oxidative stress".

Conclusion  From 2000 to 2022, the research hotspots of Ziziphi Spinosae Semen mainly focused on the chemical composition, pharmacological effects and clinical application analysis, compatibility research, formulation and preparation. Quality control and evaluation of Ziziphi Spinosae Semen, and the research on the mechanism of preventing and treating insomnia with Ziziphi Spinosae Semen may become future research directions.

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