Objective  To optimize the integrated processing technology of  Isatidis radix production and processing of origin by response surface method.

Methods  Using the content of (R,S)-goitrin, indigo, indirubin, and four glycoside active ingredients in Isatidis radix as evaluation indicators, three key process parameters were selected: fresh medicinal material moisture content(%), drying temperature (℃), and cutting specifications (mm). Box Behnken response surface design was used to systematically optimize the integrated processing and processing technology of Isatidis radix.

Results  The optimal processing conditions for the integrated processing of Isatidis radix of origin were as follows: moisture content of 40.38%, cutting size of 2.54 mm, and drying temperature of 58.57℃.

Conclusion  The integrated process method for processing and processing of  Isatidis radix established in this study is easy to operate and has good reproducibility, providing reliable technical support for standardized original processing of  Isatidis radix and having important practical application value.

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