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Center for Evidence-Based and Translational Medicine of Wuhan University
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丙酸倍氯米松吸入气雾剂中新杂质的定性定量分析
DAI Cong
TIAN Heng
WU Chunmin
YANG Yixue
BEI Qihua
YAN Quanhong
DOI:10.12173/j.issn.2097-4922.202403196
Beclomethasone propionate inhalation aerasol
Ultra-performance liquid chromatography-Q-exactive orbitrap-mass spectrometry
Discovery Studio software
New impurity
Identification
Toxicity prediction
Content determination
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HPLC-MS/MS法测定白血病患者血浆奥雷巴替尼的方法学研究及临床应用
GUO Jinyan
SUN Wenli
LIU Rui
LU Guangze
LIU Hongxing
WANG Lei
DOI:10.12173/j.issn.2097-4922.202405061
Olverembatinib
High-performance liquid chromatography tandem mass spectrometry
Therapeutic drug monitoring
Leukemia
Methodological study
Chinical application
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夫西地酸涂膜剂的制备工艺与透皮吸收研究
CHEN Hui
CAI Li
NING Lin
LUO Chunmei
DOI:10.12173/j.issn.2097-4922.202404185
Fusidic acid film
Preparation process
Response surface methodology
Transdermal absorption
High-performance liquid chromatography
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超滤离心-HPLC法测定鲁索替尼固体脂质纳米粒的包封率
FENG Shiquan
YU Jiaqi
DONG Deqiao
GAN Changran
PENG Haoyang
DUAN Chengcheng
QIN Zhenmiao
GAO Yanan
DOI:10.12173/j.issn.2097-4922.202406146
Ruxolutinib
Solid lipid nanoparticles
Melt-emulsification ultrasonic method
High performance liquid chromatography
Ultrafiltration centrifugation
Encapsulation rate
Methodology
Details
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基于HPLC-QAMS多指标成分联合OPLS-DA及加权TOPSIS模型的威灵仙药材质量评价
FENG Xiaochuan
ZHANG Jing
XU Yanzhao
ZHANG Rui
DOI:10.12173/j.issn.2097-4922.202406118
Clematidis radix et rhizoma
High-performance liquid chromatography
Stechiometry
Principal component analysis
Orthogonal partial least squares discriminant analysis
Weighted TOPSIS method
Quality evaluation
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基于UPLC-Q-Exactive-MS技术鉴定接骨七厘片的化学成分及血中移行成分
FANG Xiaoyang
ZHOU Rongrong
SHEN Bingbing
HE Weiwei
XIAO Jie
XU Jin
ZENG Hongliang
ZHANG Shuihan
DOI:10.12173/j.issn.2097-4922.202404200
Jiegu Qili tablets
Component analysis
Medicated serum
Ultra performance liquid chromatography-quadrupole-exactive-mass spectrometry
Chemical composition
Metabolites
Blood components
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LC-MS/MS测定枸橼酸西地那非中磺酸酯类基因毒性杂质
LI Cuifen
LI Jianhua
CHEN Xinguo
RUAN Pengwu
QIN Fei
DOI:10.12173/j.issn.2097-4922.202405143
Sildenafil citrate
Genotoxic impurity
Suifonate ester
Ethyl 4-ethoxy-3-formylbenzenesulfonate
High performance liquid chromatography mass spectromete
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卡瑞利珠单抗致多器官损伤不良反应的文献分析
ZHANG Yang
SU Wenyang
GAO Yue
DOI:10.12173/j.issn.2097-4922.202404099
Camrelizumab
Multiple organ injury
Adverse reactions
Literature system analysis
Immunotherapy
Programmed death protein 1
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卵泡刺激素对人卵巢颗粒KGN细胞TGF-β信号传导的影响
ZHANG Minglu
WEN Miao
YANG Zean
YU Sisi
ZHANG Yuan
WU Yanlin
DOI:10.12173/j.issn.2097-4922.202405114
Follicle stimulating hormone
Transforming growth factor-β signaling pathway
Human ovarian granulosa cells
Gene chip
Mitogen-activated protein kinases pathway
GO functional annotation
KEGG signaling pathway enrichment analysis
Smad protein
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基于液质联用法和网络药理学研究羌活治疗阿尔茨海默病的活性成分含量及作用机制
GAO Huan
XU Zihua
HU Bei
CHEN Ying
ZHAO Qingchun
DOI:10.12173/j.issn.2097-4922.202408081
Notopterygii rhizoma et radix
Network pharmacology
Mechanism
High performance liquid chromatographytandem mass spectrometry
Content determination
Alzheimer's disease
Active ingredient
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基于与标准汤剂一致性的甜叶菊配方颗粒提取工艺设计空间研究
WU Meilan
WANG Yifang
SUN Xiaoming
SUN Lien
DOI:10.12173/j.issn.2097-4922.202404072
Folium stevia
Formula granules
Standard decoction
Analytic hierarchy process method
Entropy weight method
Box-Behnken design
Design space
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通肠清胰合剂HPLC指纹图谱建立及多指标成分的含量测定
CHEN Bilin
HU Yunlian
LI Xia
LIU Zifan
XU Qian
HUANG Zhijun
DOI:10.12173/j.issn.2097-4922.202406136
Tongchang Qingyi mixture
Content determination
High performance liquid chromatography fingerprint
Cluster analysis
Principal component analysis
Quality study
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鳖甲胶特征肽的发现及其在龟甲胶中鳖甲胶成分检测上的应用
PAN Zhiwen
HUANG Wanfeng
DOI:10.12173/j.issn.2097-4922.202404194
Tortoise-shell gelatin
Turtle-shell gelatin
Specific peptide of turtle-shell gelatin
Ultra-high performance liquid chromatography triple quadrupole mass spectrometry
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伤科跌打片UPLC指纹图谱及10个成分含量测定研究
TIAN Jinmiao
ZHANG Xu
ZHOU Nan
TANG Xueting
KONG Lingfeng
ZHOU Chunling
DOI:10.12173/j.issn.2097-4922.202409066
Shangke Dieda tablets
Fingerprint
Determination
Ultra performance liquid chromatography
Paeoniae radix
Aucklandiae radix
Aurantii fructus and Citri reticulatae pericarpium viride
Rhei radix et rhizoma
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基于UPLC特征图谱和2种成分含量测定的皂角刺药材质量评价
WEI Cuijie
LIU Xiaoxia
FENG Yongwei
ZHANG Fangping
DUAN Zhiwen
XIE Wenkai
XIA Tianrui
LI Zhenyu
HE Minyou
CHEN Xiangdong
SUN Dongmei
DOI:10.12173/j.issn.2097-4922.202409023
Gleditsiae spina
Ultra performance liquid chromatography specific chromatogramt
Scopoletin
Taxifolin
Counterfeit
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