Objective  To quantitatively study the characteristics of regular medication of prescriptions for the treatment of nephropathy in Complete Book of Prescriptions of Mongolian Medicine, and to provide reference for drug research and clinical application in the treatment of kidney disease.

Methods  The prescriptions for the intervention of nephropathy in Complete Book of Prescriptions of Mongolian Medicine were collected, and the R language technology and term frequency-inverse document frequency (TF-IDF) model were used to explore and analyze the rules.

Results  A total of 113 prescriptions for the intervention of nephropathy with Mongolian medicine were collected, involving 23 medical books and 183 kinds of drugs. The most frequently used drug was white cardamom, the high-frequency drug (frequency>20) was equal to warm and cool, and the taste was mainly spicy, sweet and bitter. The drug with the highest recognition rate of TF-IDF model for cold type, febrile type, Heyi type and other nephropathy was white cardamom. A total of 46 association rules were collated, among which concanthus bean combined with white cardamom and Wulingzhi combined with white cardamom had the highest support.

Conclusion  According to the Complete Book of Prescriptions of Mongolian Medicine, the intervention of Mongolian medicine for kidney disease is centered around white cardamom, which is commonly used in combination with bitter and pungent herbs. White cardamom combined with safflower is used for the treatment of febrile nephropathy; white cardamom combined with Caesalpinia crista is used for the treatment of cold nephropathy; white cardamom combined with Hezi inhibits Heyi type nephropathy. Three new formulations of simple extracts are suitable for the three major types of kidney disease, and lay a theoretical foundation for the in-depth research and development of Mongolian medicine theory and modern pharmacology.

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